ArticleJournal of dental research2018
Complex Intratissue Microbiota Forms Biofilms in Periodontal Lesions.
Article in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Review
- Article
- Advancing periodontitis microbiome research: integrating design, analysis, and technology.Frontiers in cellular and infection microbiology · 2025Review
- Gut microbiota and metabolic profile changes unveil the deterioration of alveolar bone inflammatory resorption with aging induced by D-galactose.Scientific reports · 2024Article
- Enrichment of infection-associated bacteria in the low biomass brain bacteriota of Alzheimer's disease patients.PloS one · 2024Article
- Increasing fibroblasts and gingival collagen density in periodontitis rats by using cassava leaf extract.Journal of Taibah University Medical Sciences · 2023Article
- Emergence of Antibiotic-ResistantAntibiotics (Basel, Switzerland) · 2023Article
- "Medicine food homology" plants promote periodontal health: antimicrobial, anti-inflammatory, and inhibition of bone resorption.Frontiers in nutrition · 2023Review
- SalivaryWorld journal of gastroenterology · 2022Article
- A murine periodontitis model using coaggregation between human pathogens and a predominant mouse oral commensal bacterium.Journal of periodontal & implant science · 2022Article
- Analysis of the effects of prepared porcelain veneers and unprepared porcelain veneers on gingival crevicular flora based on high-throughput sequencing.Experimental and therapeutic medicine · 2021Article
- Optimal specimen type for accurate diagnosis of infectious peripheral pulmonary lesions by mNGS.BMC pulmonary medicine · 2020Article
- Article
- The Bacterial Connection between the Oral Cavity and the Gut Diseases.Journal of dental research · 2020Review
- Proteome and Microbiome Mapping of Human Gingival Tissue in Health and Disease.Frontiers in cellular and infection microbiology · 2020Article
- Article
- Article
- Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues.Journal of clinical medicine · 2019Review
- Chronic Inflammation as a Link between Periodontitis and Carcinogenesis.Mediators of inflammation · 2019Review
- An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis.Journal of clinical periodontology · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is caused by dysbiotic subgingival bacterial communities that may lead to increased bacterial invasion into gingival tissues. Although shifts in community structures associated with transition from health to periodontitis have been well characterized, the nature of bacteria present within the gingival tissue of periodontal lesions is not known. To characterize microbiota within tissues of periodontal lesions and compare them with plaque microbiota, gingival tissues and subgingival plaques were obtained from 7 patients with chronic periodontitis. A sequencing analysis of the 16S rRNA gene revealed that species richness and diversity were not significantly different between the 2 groups. However, intersubject variability of intratissue communities was smaller than that of plaque communities. In addition, when compared with the plaque communities, intratissue communities were characterized by decreased abundance of Firmicutes and increased abundance of Fusobacteria and Chloroflexi. In particular, Fusobacterium nucleatum and Porphyromonas gingivalis were highly enriched within the tissue, composing 15% to 40% of the total bacteria. Furthermore, biofilms, as visualized by alcian blue staining and atomic force microscopy, were observed within the tissue where the degradation of connective tissue fibers was prominent. In conclusion, very complex bacterial communities exist in the form of biofilms within the gingival tissue of periodontal lesions, which potentially serve as a reservoir for persistent infection. This novel finding may prompt new research on therapeutic strategies to treat periodontitis.
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