Evidence map›Paper›PMID 28945472›Full record

ArticleAnnals of the American Thoracic Society2017

Immune Tolerance, Xenografts, and Large-Animal Studies in Transplantation.

David H Sachs

Abstract read
In one paragraph

Article in Annals of the American Thoracic Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Blastocyst complementation and interspecies chimeras in gene edited pigs.Frontiers in cell and developmental biology · 2022
    Review
  3. IL-27 RαJournal of cellular and molecular medicine · 2020
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David H SachsDepartment of Surgery, Columbia University Medical Center, New York, New York.

Funding

XENOGRAFT TOLERANCE THROUGH MIXED CHIMERISMP01AI045897 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Megan Sykes · 2000 to 2026
$71.9M
TOLERANCE TO VASCULARIZED ALLOGRAFTS IN MINISWINER37AI031046 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI SACHS, DAVID H · 2006 to 2015
$7.3M
NIAID NIH HHS P01 AI045897NIAID NIH HHS R37 AI031046
6 · The paper itself

Abstract

This article summarizes studies in which the author has been involved over several decades, directed toward providing solutions for the three major limitations to the field of transplantation: (1) drug treatment-related complications; (2) chronic rejection; and (3) the availability of transplantable organs. The first two of these limitations may be overcome by induction of transplantation tolerance, while the third will also require a new source of organs, for which great strides are now being made in xenotransplantation through genetic engineering.

Indexed as

HeterograftsImmune ToleranceTransplantation, HeterologousAnimalsDisease Models, AnimalGenetic EngineeringTransplantation Tolerancetolerancetransplantationxenotransplantation

Identifiers

PMID28945472
PMCPMC5711340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.