Evidence map›Paper›PMID 28945296›Full record

ArticleHead & neck2017

Prognostic biomarkers in patients with human immunodeficiency virus-positive disease with head and neck squamous cell carcinoma.

Hongzheng Zhang, Sungjin Kim, Zhengjia Chen, Sreenivas Nannapaneni, Amy Y Chen, Charles E Moore, Gabriel Sica, Marina Mosunjac, Minh Ly T Nguyen, Gypsyamber D'Souza and 22 more

Open access · greenAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head & neck, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Incidence and survival of HNSCC patients living with HIV compared with HIV-negative HNSCC patients.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 10 institutions in 1 country.

Hongzheng ZhangDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.
Sungjin KimBiostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, California.
Zhengjia ChenDepartment of Biostatistics and Bioinformatics, Emory University School of Medicine, Atlanta, Georgia.
Sreenivas NannapaneniDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.
Amy Y ChenDepartment of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia.
Charles E MooreDepartment of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia.
Gabriel SicaDepartment of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia.
Marina MosunjacDepartment of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia.
Minh Ly T NguyenDepartment of Internal Medicine, Emory University School of Medicine, Atlanta, Georgia.
Gypsyamber D'SouzaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Thomas E CareyDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Lisa A PetersonDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Jonathan B McHughDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Martin GrahamDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Christine M KomarckDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Gregory T WolfDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Heather M WallineDepartment of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.
Emily BellileDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan.
James RiddellDepartment of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan.
Sara I PaiDepartment of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
David SidranskyDepartment of Otolaryngology/Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland.
William H WestraDepartments of Pathology Otolaryngology/Head and Neck Surgery Oncology, Johns Hopkins University, Baltimore, Maryland.
William N WilliamDepartment of Head and Neck Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas.
J Jack LeeDepartment of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, Texas.
Adel K El-NaggarDepartment of Pathology, Department of Head and Neck Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas.
Robert L FerrisDepartment of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Raja SeethalaDepartment of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Jennifer R GrandisDepartment of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Zhuo Georgia ChenDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.
Nabil F SabaDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0003-4972-1477
Dong M ShinDepartment of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-8245-4174
Head and Neck Cancer SPORE HIV supplement consortium
Emory University · USUniversity of Michigan · USJohns Hopkins University · USThe University of Texas MD Anderson Cancer Center · USEmory University Hospital · USCedars-Sinai Medical Center · USHarvard University · USUniversity of California, San Francisco · USUniversity of Pittsburgh · USUniversity of Pittsburgh Medical Center · US

Funding

TUMOR SUPPRESOR GENE PROMOTER HYPERMETHYLATION FOR DETECTION OF HEAD AND NECKP50DE019032 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI SIDRANSKY, DAVID · 2007 to 2016
$27.1M
NIDCR NIH HHS P50 DE019032
6 · The paper itself

Abstract

backgroundWe examined the prognostic value of a panel of biomarkers in patients with squamous cell carcinoma of the head and neck (SCCHN) who were human immunodeficiency virus (HIV) positive (HIV-positive head and neck cancer) and HIV negative (HIV-negative head and neck cancer).

methodsTissue microarrays (TMAs) were constructed using tumors from 41 disease site-matched and age-matched HIV-positive head and neck cancer cases and 44 HIV-negative head and neck cancer controls. Expression of tumor biomarkers was assessed by immunohistochemistry (IHC) and correlations examined with clinical variables.

resultsExpression levels of the studied oncogenic and inflammatory tumor biomarkers were not differentially regulated by HIV status. Among patients with HIV-positive head and neck cancer, laryngeal disease site (P = .003) and Clavien-Dindo classification IV (CD4) counts <200 cells/μL (P = .01) were associated with poor prognosis. Multivariate analysis showed that p16 positivity was associated with improved overall survival (OS; P < .001) whereas increased expression of transforming growth factor-beta (TGF-β) was associated with poor clinical outcome (P = .001).

conclusionDisease site has significant effect on the expression of biomarkers. Expression of tumor TGF-β could be a valuable addition to the conventional risk stratification equation for improving head and neck cancer disease management strategies.

Indexed as

AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesCause of DeathCombined Modality TherapyDisease-Free SurvivalFemaleHead and Neck NeoplasmsHIV InfectionsHIV SeropositivityHumansKaplan-Meier EstimateLogistic ModelsBiomarkers, TumorTransforming Growth Factor beta1biomarkershead and neck cancerhuman immunodeficiency virus (HIV)prognosissurvival

Identifiers

PMID28945296
PMCPMC5808949
OpenAlexW2759063327

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.