Evidence map›Paper›PMID 28945245›Full record

ArticleNature immunology2017

Identification of lineage-specifying cytokines that signal all CD8

Ruth Etzensperger, Tejas Kadakia, Xuguang Tai, Amala Alag, Terry I Guinter, Takeshi Egawa, Batu Erman, Alfred Singer

Open access · greenAbstract read
In one paragraph

Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. T Cell Development: From T-Lineage Specification to Intrathymic Maturation.Advances in experimental medicine and biology · 2025
    Review
  10. Article
  11. Article
  12. Article
  13. TGF-β Regulation of T Cells.Annual review of immunology · 2023
    Review
  14. Article
  15. Article
  16. A Beginner's Guide to T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023
    Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Ruth EtzenspergerExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Tejas KadakiaExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Xuguang TaiExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Amala AlagExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Terry I GuinterExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Takeshi EgawaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.ORCID http://orcid.org/0000-0001-7489-1051
Batu ErmanMolecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey.
Alfred SingerExperimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
National Institutes of Health · USSabancı Üniversitesi · TRWashington University in St. Louis · US

Funding

Cytokine signaling in developing thymocytes and T cellsZIABC011111 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 2009 to 2023
$4.8M
T CELL DIFFERENTIATION AND REPERTOIRE SELECTIONZ01BC009273 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SINGER, ALFRED · 1996 to 2008
$2.9M
GENE REGULATION GOVERNING T LYMPHOCYTE FATE DECISIONSR01AI097244 · NIAID · WASHINGTON UNIVERSITY · PI EGAWA, TAKESHI · 2012 to 2016
$1.9M
Intramural NIH HHS Z01 BC009273NIAID NIH HHS R01 AI097244
6 · The paper itself

Abstract

T cell antigen receptor (TCR) signaling in the thymus initiates positive selection, but the CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesCell LineageCore Binding Factor Alpha 3 SubunitCytokinesFlow CytometryGene ExpressionMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Antigen, T-CellReverse Transcriptase Polymerase Chain ReactionSignal TransductionThymocytesThymus GlandCore Binding Factor Alpha 3 SubunitCytokinesReceptors, Antigen, T-CellRunx3 protein, mouse

Identifiers

PMID28945245
PMCPMC5659273
OpenAlexW2759854535

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.