Evidence map›Paper›PMID 28945243›Full record

ArticleNature immunology2017

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8

Abigail Culshaw, Kristin Ladell, Stephanie Gras, James E McLaren, Kelly L Miners, Carine Farenc, Heleen van den Heuvel, Emma Gostick, Wanwisa Dejnirattisai, Apirath Wangteeraprasert and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. T Cell Responses During Dengue Infection.Current topics in microbiology and immunology · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. The molecular mechanisms of CD8Frontiers in immunology · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. TCR Recognition of Peptide-MHC-I: Rule Makers and Breakers.International journal of molecular sciences · 2020
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Abigail CulshawDepartment of Medicine, Imperial College London, London, UK.
Kristin LadellInstitute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.ORCID http://orcid.org/0000-0002-9856-2938
Stephanie GrasInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
James E McLarenInstitute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Kelly L MinersInstitute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Carine FarencInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Heleen van den HeuvelInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Emma GostickInstitute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Wanwisa DejnirattisaiDepartment of Medicine, Imperial College London, London, UK.
Apirath WangteeraprasertDepartment of Medicine, Imperial College London, London, UK.
Thaneeya DuangchindaMedical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Pathum Thani, Thailand.
Pojchong ChotiyarnwongDepartment of Medicine, Imperial College London, London, UK.
Wannee LimpitikulPediatric Department, Songkhla Hospital, Ministry of Public Health, Songkhla, Thailand.
Sirijitt VasanawathanaPediatric Department, Khon Kaen Hospital, Ministry of Public Health, Khon Kaen, Thailand.
Prida MalasitDengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tao DongMedical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Jamie RossjohnInstitute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Juthathip MongkolsapayaDepartment of Medicine, Imperial College London, London, UK.
David A PriceInstitute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Gavin R ScreatonDepartment of Medicine, Imperial College London, London, UK.

Funding

Medical Research Council G0600000Medical Research Council G0600520Medical Research Council G0801508Medical Research Council G1001046Medical Research Council MR/L018942/1
6 · The paper itself

Abstract

Adaptive immune responses protect against infection with dengue virus (DENV), yet cross-reactivity with distinct serotypes can precipitate life-threatening clinical disease. We found that clonotypes expressing the T cell antigen receptor (TCR) β-chain variable region 11 (TRBV11-2) were 'preferentially' activated and mobilized within immunodominant human-leukocyte-antigen-(HLA)-A*11:01-restricted CD8

Indexed as

Adaptive ImmunityAmino Acid SequenceCD8-Positive T-LymphocytesComplementarity Determining RegionsCross ReactionsDengueDengue VirusEpitopes, T-LymphocyteGerm-Line MutationHLA-A AntigensHumansModels, MolecularProtein Structure, TertiaryReceptors, Antigen, T-Cell, alpha-betaSerine EndopeptidasesSerotypingComplementarity Determining RegionsEpitopes, T-LymphocyteHLA-A AntigensNS3 protease, dengue virusReceptors, Antigen, T-Cell, alpha-betaSerine EndopeptidasesViral Proteases

Identifiers

PMID28945243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.