Evidence map›Paper›PMID 28945222›Full record

ArticleNature neuroscience2017

Synapse-specific astrocyte gating of amygdala-related behavior.

Mario Martin-Fernandez, Stephanie Jamison, Laurie M Robin, Zhe Zhao, Eduardo D Martin, Juan Aguilar, Michael A Benneyworth, Giovanni Marsicano, Alfonso Araque

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 204 papers.

0numbers the graph read from it
0cells of the map it votes in
204citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

204 citing papers in PubMed, 346 citations in OpenAlex.

  1. Review
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  6. Hippocampal astrocytic sequences emerge during learning and memory.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. Review
  9. Article
  10. Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Astrocyte Regulation of Spinal Circuit Function.Journal of neurochemistry · 2026
    Review
  15. Article
  16. Astrocyte CBJournal of neuroinflammation · 2026
    Article
  17. Article
  18. Article
  19. Complex dynamics of glutamate-induced calcium responses in astrocytes from the nucleus of the solitary tract of mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  20. Article

144 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Mario Martin-FernandezDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Stephanie JamisonDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.
Laurie M RobinINSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.
Zhe ZhaoINSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.
Eduardo D MartinInstituto Cajal, Consejo Superior de Investigaciones Científicas. Madrid, Spain.
Juan AguilarHospital Nacional de Parapléjicos, Servicio de Salud de Castilla-La Mancha, Toledo, Spain.ORCID http://orcid.org/0000-0002-8070-3923
Michael A BenneyworthMouse Behavior Core, University of Minnesota, Minneapolis, Minnesota, USA.
Giovanni MarsicanoINSERM, U1215 NeuroCentre Magendie, Endocannabinoids and Neuroadaptation, Bordeaux, France.
Alfonso AraqueDepartment of Neuroscience, University of Minnesota, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0003-3840-1144
University of Minnesota · USUniversité de Bordeaux · FRConsejo Superior de Investigaciones Científicas · ESServicio de Salud de Castilla La Mancha · ES

Funding

Astrocyte-neuron interaction in behavior driven by striatal information processingR01NS097312 · NINDS · UNIVERSITY OF MINNESOTA · PI ARAQUE, ALFONSO, REDISH, A DAVID · 2016 to 2019
$1.8M
NINDS NIH HHS R01 NS097312
6 · The paper itself

Abstract

The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely focused on neuronal function and connectivity. Astrocytes functionally interact with neurons, but their role in the amygdala remains largely unknown. We show that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits. To investigate the role of astrocytes in amygdala-related behavior and identify the underlying synaptic mechanisms, we used exogenous or endogenous signaling to selectively activate CeM astrocytes. Astrocytes depressed excitatory synapses from basolateral amygdala via A

Indexed as

6-Cyano-7-nitroquinoxaline-2,3-dioneAdenosine A2 Receptor AntagonistsAmygdalaAnimalsAstrocytesFearMaleMaze LearningMiceMice, Inbred C57BLMice, KnockoutNerve NetOrgan Culture TechniquesReceptor, Adenosine A2ASynapses6-Cyano-7-nitroquinoxaline-2,3-dioneAdenosine A2 Receptor AntagonistsReceptor, Adenosine A2A

Identifiers

PMID28945222
PMCPMC5903286
OpenAlexW2759821008

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.