Evidence map›Paper›PMID 28945118›Full record

Trial reportThe American journal of psychiatry2018

Psychopharmacological Treatment in the RAISE-ETP Study: Outcomes of a Manual and Computer Decision Support System Based Intervention.

Delbert G Robinson, Nina R Schooler, Christoph U Correll, Majnu John, Benji T Kurian, Patricia Marcy, Alexander L Miller, Ronny Pipes, Madhukar H Trivedi, John M Kane

Registry-linked trialOpen access · bronzeAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03695289 (Adaptation of an Evidence-based Interactive Obesity Treatment Approach), which is not on this map. Cited by 34 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 7 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03695289 nacompletednot on this map

Adaptation of an Evidence-based Interactive Obesity Treatment Approach (iOTA) for Obesity Prevention in Serious Mental Illness

TypeinterventionalSponsorWashington University School of MedicineRan2018 to 2020Enrolled30ConditionsObesity, Mentally Ill PersonsArmsiOTA SMI, Health Education Control
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 7 syntheses or guidelines pooled it, 72 citations in OpenAlex.

  1. Guideline
  2. Collaborative care approaches for people with severe mental illness.The Cochrane database of systematic reviews · 2024
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Pharmacological Augmentation in Unipolar Depression: A Guide to the Guidelines.The international journal of neuropsychopharmacology · 2020
    Pooled it
  6. Specialised early intervention teams for recent-onset psychosis.The Cochrane database of systematic reviews · 2020
    Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Delbert G RobinsonFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Nina R SchoolerFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Christoph U CorrellFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Majnu JohnFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Benji T KurianFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Patricia MarcyFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Alexander L MillerFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Ronny PipesFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Madhukar H TrivediFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
John M KaneFrom the Feinstein Institute for Medical Research, Center for Psychiatric Neuroscience, Manhasset, N.Y.; the Departments of Psychiatry and of Molecular Medicine, Hofstra Northwell School of Medicine, Hempstead, N.Y.; Psychiatry Research, Zucker Hillside Hospital, Northwell Health, Glen Oaks, N.Y.; the Department of Psychiatry, SUNY Downstate Medical Center, Brooklyn, N.Y.; the Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, N.Y.; the Department of Mathematics, Hofstra University, Hempstead, N.Y.; University of Texas Southwestern Medical Center, Dallas; and the Department of Psychiatry, University of Texas Health Science Center at San Antonio.
Feinstein Institute for Medical Research · US

Funding

Trials Operation Unit (OPERATIONS CORE)P30MH090590 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CORRELL, CHRISTOPH U · 2010 to 2014
$7.9M
NIMH NIH HHS HHSN271200900019CNIMH NIH HHS P30 MH090590
6 · The paper itself

Abstract

objectiveThe Recovery After an Initial Schizophrenia Episode-Early Treatment Program compared NAVIGATE, a comprehensive program for first-episode psychosis, to clinician-choice community care over 2 years. Quality of life and psychotic and depressive symptom outcomes were found to be better with NAVIGATE. Compared with previous comprehensive first-episode psychosis interventions, NAVIGATE medication treatment included unique elements of detailed first-episode-specific psychotropic medication guidelines and a computerized decision support system to facilitate shared decision making regarding prescriptions. In the present study, the authors compared NAVIGATE and community care on the psychotropic medications prescribed, side effects experienced, metabolic outcomes, and scores on the Adherence Estimator scale, which assesses beliefs related to nonadherence.

methodPrescription data were obtained monthly. At baseline and at 3, 6, 12, 18, and 24 months, participants reported whether they were experiencing any of 21 common antipsychotic side effects, vital signs were obtained, fasting blood samples were collected, and the Adherence Estimator scale was completed.

resultsOver the 2-year study period, compared with the 181 community care participants, the 223 NAVIGATE participants had more medication visits, were more likely to receive a prescription for an antipsychotic and more likely to receive one conforming to NAVIGATE prescribing principles, and were less likely to receive a prescription for an antidepressant. NAVIGATE participants experienced fewer side effects and gained less weight; other vital signs and cardiometabolic laboratory findings did not differ between groups. Adherence Estimator scores improved in the NAVIGATE group but not in the community care group.

conclusionsAs part of comprehensive care services, medication prescription can be optimized for first-episode psychosis, contributing to better outcomes with a lower side effect burden than standard care.

Indexed as

Decision Support Systems, ClinicalAdolescentAdultAntidepressive AgentsAntipsychotic AgentsBlood GlucoseBlood PressureBody Mass IndexCholesterolCholesterol, HDLCholesterol, LDLCommunity Mental Health ServicesDepressionEarly Medical InterventionFemaleGlycated HemoglobinAntidepressive AgentsAntipsychotic AgentsBlood GlucoseCholesterolCholesterol, HDLCholesterol, LDLGlycated Hemoglobinhemoglobin A1c protein, humanInsulinPsychotropic DrugsTriglyceridesAntipsychoticsMedication AdherenceMetabolic OutcomesPsychosisSchizophreniaSide Effects

Identifiers

PMID28945118
PMCPMC5794655
OpenAlexW2755355234

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.