ArticleACS chemical biology2017
Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.
Article in ACS chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Large-scale discovery platform enables identification of peptides targeting drug-resistant candidiasis.Cell reports methods · 2026Article
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- Inverse stable isotope labeling (InverSIL) links predicted catecholate siderophore gene clusters to their products in diverse bacteria.bioRxiv : the preprint server for biology · 2025Article
- Microbial Siderophores: A New Insight on Healthcare Applications.BME frontiers · 2025Review
- The Complete Genomic Sequence of Microbial Transglutaminase Producer, Streptomyces mobaraensis DSM40587.Biochemical genetics · 2024Article
- Heterologous Production and Biosynthesis of Threonine-16:0dioic acids with a Hydroxamate Moiety.Journal of natural products · 2023Article
- Megalochelin, a Tridecapeptide Siderophore from a Talented Streptomycete.ACS chemical biology · 2023Article
- Lunaemycins, New Cyclic Hexapeptide Antibiotics from the Cave Moonmilk-DwellerInternational journal of molecular sciences · 2023Article
- The ubiquitous catechol moiety elicits siderophore and angucycline production in Streptomyces.Communications chemistry · 2022Article
- Isolation and Evaluation of Rhizosphere Actinomycetes With Potential Application for BiocontrollingFrontiers in microbiology · 2021Article
- Cloning and Overexpression of theFrontiers in microbiology · 2020Article
- Article
- Antifungal, Plant Growth-Promoting, and Genomic Properties of an Endophytic ActinobacteriumFrontiers in microbiology · 2019Article
- Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline.Proteomics · 2018Review
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8 authors.
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Abstract
The explosive increase in genome sequencing and the advances in bioinformatic tools have revolutionized the rationale for natural product discovery from actinomycetes. In particular, this has revealed that actinomycete genomes contain numerous orphan gene clusters that have the potential to specify many yet unknown bioactive specialized metabolites, representing a huge unexploited pool of chemical diversity. Here, we describe the discovery of a novel group of catecholate-hydroxamate siderophores termed qinichelins (2-5) from Streptomyces sp. MBT76. Correlation between the metabolite levels and the protein expression profiles identified the biosynthetic gene cluster (named qch) most likely responsible for qinichelin biosynthesis. The structure of the molecules was elucidated by bioinformatics, mass spectrometry, and NMR. The genome of Streptomyces sp. MBT76 contains three gene clusters for the production of catecholate-peptide siderophores, including a separate cluster for the production of a shared catecholate precursor. In addition, an operon in the qch cluster was identified for the production of the ornithine precursor for qinichelins, independent of primary metabolism. This biosynthetic complexity provides new insights into the challenges scientists face when applying synthetic biology approaches for natural product discovery.
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