ArticleMolecular medicine reports2017
Polyaniline promotes peripheral nerve regeneration by enhancement of the brain‑derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway.
Article in Molecular medicine reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 42 citations in OpenAlex.
- Enhancing peripheral nerve regeneration in aging: the role of Schwann cells, c-Jun, and emerging therapeutic strategies.GeroScience · 2026Review
- Advances in sciatic nerve regeneration: A review of contemporary techniques.Regenerative therapy · 2025Review
- The Application of Stem Cells and Exosomes in Promoting Nerve Conduits for Peripheral Nerve Repair.Biomaterials research · 2025Review
- Recent advances in 3D printable conductive hydrogel inks for neural engineering.Nano convergence · 2023Review
- Research progress on the reduced neural repair ability of aging Schwann cells.Frontiers in cellular neuroscience · 2023Review
- Electroconductive PEDOT nanoparticle integrated scaffolds for spinal cord tissue repair.Biomaterials research · 2022Article
- Electrospun conductive nanofiber yarns for accelerating mesenchymal stem cells differentiation and maturation into Schwann cell-like cells under a combination of electrical stimulation and chemical induction.Acta biomaterialia · 2022Article
- Treadmill exercise activates ATF3 and ERK1/2 downstream molecules to facilitate axonal regrowth after sciatic nerve injury.Journal of exercise rehabilitation · 2020Article
- Dl-3-n-Butylphthalide Alleviates Hippocampal Neuron Damage in Chronic Cerebral HypoperfusionFrontiers in aging neuroscience · 2020Article
- Current and novel polymeric biomaterials for neural tissue engineering.Journal of biomedical science · 2018Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A previous study has demonstrated a progression in the nerve regeneration by polyaniline/cellulose (PANI/RC), although the underlying mechanism was not elucidated. In the present study, regenerated nerves were investigated, using histological techniques, functional assays and western blot analysis. The triceps surae muscle weight ratio percentages of the sham, regenerated cellulose (RC) and the PANI/RC groups were 38.88±4.76 and 76.32±7.11%, respectively. The thickness of the myelin sheath for the aforementioned groups were as follows: 1.2±0.27; 0.49±0.21 and 0.93±0.28 µl. Western blot analysis demonstrated that the ciliary neurotrophic factor (CNTF) and brain‑derived neurotrophic factor (BDNF) were highly expressed in the regenerated nerve in the presence of polyaniline. Phosphorylated extracellular kinase (p‑ERK)1/2 expression in the PANI/RC group was significantly elevated compared with the RC group (1.83‑fold) and the sham group (4.92‑fold). The expression of the axon sprout‑associated proteins, such as Tau, α‑tubulin and growth associated protein‑43, were increased (1.64, 1.59 and 1.24‑fold, respectively) compared with the RC group. The results demonstrated that PANI enhances the expression and secretion of BDNF and CNTF, activates the ERK1/2 signaling pathway and increases the expression levels of the GAP‑43, Tau and α‑tubulin, suggesting an insight into nerve regeneration and possible clinical interventions in nerve injury.
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