Evidence map›Paper›PMID 28944780›Full record

ReviewNature reviews. Genetics2017

Demographic history, selection and functional diversity of the canine genome.

Elaine A Ostrander, Robert K Wayne, Adam H Freedman, Brian W Davis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

97 citing papers in PubMed.

  1. Article
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  8. GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Genetic testing predicts appearance but not behavior in dogs.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Copy-cat evolution: Divergence and convergence within and between cat and dog breeds.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Article
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  20. Article

37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elaine A OstranderCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, 50 South Drive, Building 50, National Institutes of Health, Bethesda, Maryland 20892, USA.
Robert K WayneDepartment of Ecology and Evolutionary Biology, 601 Charles E Young Drive South, University of California at Los Angeles, Los Angeles, California 90095, USA.
Adam H FreedmanInformatics Division, Department of Organismic and Evolutional Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Brian W DavisCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, 50 South Drive, Building 50, National Institutes of Health, Bethesda, Maryland 20892, USA.

Funding

Comparative Mammalian GenomicsZIAHG200377 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI OSTRANDER, ELAINE · 2012 to 2025
$24.8M
6 · The paper itself

Abstract

The domestic dog represents one of the most dramatic long-term evolutionary experiments undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in phenotype and behaviour has developed in dogs, providing a model for understanding the developmental and genomic mechanisms of diversification. We discuss pattern and process in domestication, beginning with general findings about early domestication and problems in documenting selection at the genomic level. Furthermore, we summarize genotype-phenotype studies based first on single nucleotide polymorphism (SNP) genotyping and then with whole-genome data and show how an understanding of evolution informs topics as different as human history, adaptive and deleterious variation, morphological development, ageing, cancer and behaviour.

Indexed as

Polymorphism, Single NucleotideWhole Genome SequencingAnimalsBehavior, AnimalDog DiseasesDogsDomesticationNeoplasmsSelection, GeneticSelective Breeding

Identifiers

PMID28944780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.