Evidence map›Paper›PMID 28944345›Full record

ArticleMachine learning in medical imaging. MLMI (Workshop)2016

Functional Connectivity Network Fusion with Dynamic Thresholding for MCI Diagnosis.

Xi Yang, Yan Jin, Xiaobo Chen, Han Zhang, Gang Li, Dinggang Shen

Abstract read
In one paragraph

Article in Machine learning in medical imaging. MLMI (Workshop), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Multiple functional connectivity networks fusion for schizophrenia diagnosis.Medical & biological engineering & computing · 2020
    Article
  5. Multi-task fused sparse learning for mild cognitive impairment identification.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xi YangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Yan JinDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Xiaobo ChenDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Han ZhangDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Gang LiDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Dinggang ShenDepartment of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

Quantifying Brain Abnormality by Multimodality Neuroimage Analysis,R01AG041721 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIU, MINGXIA · 2012 to 2019
$3.0M
Assessing Large-scale Brain Connectivities in Mild Cognitive ImpairmentR01AG042599 · NIA · UNIVERSITY OF GEORGIA · PI LIU, TIANMING · 2013 to 2017
$1.4M
Diagnosis of Alzheimer's Disease Using Dynamic High-Order Brain NetworksR01EB022880 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2016 to 2018
$1.1M
NIA NIH HHS R01 AG041721NIA NIH HHS R01 AG042599NIBIB NIH HHS R01 EB022880
6 · The paper itself

Abstract

The resting-state functional MRI (rs-fMRI) has been demonstrated as a valuable neuroimaging tool to identify mild cognitive impairment (MCI) patients. Previous studies showed network breakdown in MCI patients with thresholded rs-fMRI connectivity networks. Recently, machine learning techniques have assisted MCI diagnosis by integrating information from multiple networks constructed with a range of thresholds. However, due to the difficulty of searching optimal thresholds, they are often predetermined and uniformly applied to the entire network. Here, we propose an element-wise thresholding strategy to dynamically construct multiple functional networks, i.e., using possibly different thresholds for different elements in the connectivity matrix. These dynamically generated networks are then integrated with a network fusion scheme to capture their common and complementary information. Finally, the features extracted from the fused network are fed into support vector machine (SVM) for MCI diagnosis. Compared to the previous methods, our proposed framework can greatly improve MCI classification performance.

Identifiers

PMID28944345
PMCPMC5609704

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.