ArticleInternational journal of ophthalmology2017
Systematic review and Meta-analysis comparing modified cross-linking and standard cross-linking for progressive keratoconus.
Article in International journal of ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The efficacy of standard versus accelerated epi-off corneal cross-linking protocols: a systematic review and sub-group analysis.International ophthalmology · 2019Pooled it
- Three-year results of accelerated transepithelial cross-linking (30 mW/cmBMJ open ophthalmology · 2022Trial
- Ten Years' Experience Using Proxymetacaine Hydrochloride 0.5% for Postoperative Pain Control in Epithelium-Off Corneal Crosslinking.Journal of clinical medicine · 2025Article
- Hyperbaric Oxygenation Increases Available Oxygen and Resistance to Enzymatic Digestion in Accelerated Corneal Collagen Crosslinking.Translational vision science & technology · 2025Article
- Long-term Effects and Prognostic Factors of Accelerated Cross-Linking with Retention Ring-assisted Riboflavin Application on Keratoconus Progression.Korean journal of ophthalmology : KJO · 2025Article
- Pain mechanisms and management in corneal cross-linking: a review.BMJ open ophthalmology · 2021Review
- Accelerated and Standard Corneal Cross-Linking Protocols in Patients with Down Syndrome: A Non-inferiority Contralateral Randomized Trial.Ophthalmology and therapy · 2020Article
- Prospective 2-year study of accelerated pulsed transepithelial corneal crosslinking outcomes for Keratoconus.Eye (London, England) · 2019Article
- Effect of the retention ring-assisted continuous application of riboflavin in pulsed-light accelerated corneal collagen cross-linking on the progression of keratoconus.BMC ophthalmology · 2019Article
- Corneal Collagen Cross-Linking in the Stabilization of Keratoconus.Deutsches Arzteblatt international · 2019Review
- Accelerated versus standard corneal cross linking in the treatment of ectasia post refractive surgery and penetrating keratoplasty: a medium term randomized trial.International journal of ophthalmology · 2019Article
- Study of Demarcation Line Depth in Transepithelial versus Epithelium-Off Accelerated Cross-Linking (AXL) in Keratoconus.Journal of ophthalmology · 2019Article
- Effects of collagen cross-linking on the keratoconus metabolic network.Eye (London, England) · 2018Article
- Epi-Off versus Epi-On Corneal Collagen Cross-Linking in Keratoconus Patients: A Comparative Study through 2-Year Follow-Up.Journal of ophthalmology · 2018Article
- Corneal Collagen Cross-Linking Using Epithelium Disruptor Instrument in Progressive Keratoconus.Journal of current ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo compare the effectiveness and safety between modified cross-linking (MC) and standard cross-linking (SC) in mild or moderate progressive keratoconus.
methodsEligible studies were retrieved from four electronic databases, including CENTRAL, Clinical Trials gov, PupMed and OVID MEDLINE. We set post-surgical maximum K value (Kmax) as the primary outcome. In addition, uncorrected and corrected distant visual acuity (UDVA and UDVA), spherical equivalent (SE), endothelial cell density (ECD), central cornea thickness (CCT) and depth of demarcation line (DDL) were Meta-analyzed as secondary outcomes. Mean differences for these outcomes were pooled through either a random-effect model or fixed-effect model according to data heterogeneity.
resultsTwenty-four comparative studies either on accelerated cross-linking (AC) compared with SC or on trans-epithelial cross-linking (TC) compared with SC were included and pooled for analysis. The results indicated that MC was significantly inferior to SC at delaying Kmax deterioration [AC
conclusionSC is more favorable at halting the progression of keratoconus, but visual acuity improvement showed comparable results between MCs and SC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.