Evidence map›Paper›PMID 28944092›Full record

ArticleJournal of vaccines & vaccination2017

MEFA (multiepitope fusion antigen)-Novel Technology for Structural Vaccinology, Proof from Computational and Empirical Immunogenicity Characterization of an Enterotoxigenic

Qiangde Duan, Kuo Hao Lee, Rahul M Nandre, Carolina Garcia, Jianhan Chen, Weiping Zhang

Open access · hybridAbstract read
In one paragraph

Article in Journal of vaccines & vaccination, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Applied and environmental microbiology · 2026
    Article
  2. Review
  3. Recent progress in enterotoxigenicInfection and immunity · 2025
    Review
  4. Characterization ofApplied and environmental microbiology · 2025
    Article
  5. A polyvalent multiepitope protein cross-protects againstProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Development of an enterotoxigenicHuman vaccines & immunotherapeutics · 2019
    Review
  19. Article
  20. Co-administered Tag-Less Toxoid Fusion 3xSTaFrontiers in microbiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qiangde DuanDepartment of Diagnostic Medicine/Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA.
Kuo Hao LeeDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
Rahul M NandreDepartment of Diagnostic Medicine/Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA.
Carolina GarciaDepartment of Diagnostic Medicine/Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA.
Jianhan ChenDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USA.
Weiping ZhangDepartment of Diagnostic Medicine/Pathobiology, Kansas State University College of Veterinary Medicine, Manhattan, KS 66506, USA.
Kansas State University · US

Funding

A broadly protective subunit vaccine against enterotoxigenic Escherichia coli (ETEC) associateddiarrheaR01AI121067 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZHANG, WEIPING · 2016 to 2020
$2.0M
Multi-scale enhanced sampling of disordered proteins: Admin Supplement InstrumentationR01GM114300 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI CHEN, JIANHAN · 2016 to 2020
$1.5M
NIAID NIH HHS R01 AI121067NIGMS NIH HHS R01 GM114300
6 · The paper itself

Abstract

Vaccine development often encounters the challenge of virulence heterogeneity. Enterotoxigenic

Indexed as

DiarrheaETEC (enterotoxigenic Escherichia coli)MEFA (multiepitope fusion antigen)Multivalent vaccineStructural vaccinology

Identifiers

PMID28944092
PMCPMC5606245
OpenAlexW2751224524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.