Evidence map›Paper›PMID 28944057›Full record

ArticleJournal of materials chemistry. B2016

Bright and Stable Near-Infrared Pluronic-Silica Nanoparticles as a Contrast Agent for

Lesan Yan, Huiquan Wang, Anqi Zhang, Calvin Zhao, Yongping Chen, Xingde Li

Abstract read
In one paragraph

Article in Journal of materials chemistry. B, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  5. Article
  6. Minimizing ATP depletion by oxygen scavengers for single-molecule fluorescence imaging in live cells.Proceedings of the National Academy of Sciences of the United States of America · 2018
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lesan YanDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205.
Huiquan WangSchool of Electronics and Information Engineering, Tianjin Polytechnic University, Tianjin, 3000387, China.
Anqi ZhangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205.
Calvin ZhaoDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205.
Yongping ChenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205.
Xingde LiDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21205.

Funding

ValidationU54CA151838 · NCI · JOHNS HOPKINS UNIVERSITY · PI POMPER, MARTIN G, SEARSON, PETER C · 2010 to 2014
$11.9M
Nonlinear Optical Endomicroscopy for Optical Biopsy of Cancer in Internal OrgansR01CA153023 · NCI · JOHNS HOPKINS UNIVERSITY · PI LI, XINGDE · 2011 to 2015
$2.6M
Molecular Contrast Agents Based on Gold Nanocages for OCT Imaging of CancerR01CA120480 · NCI · UNIVERSITY OF WASHINGTON · PI LI, XINGDE · 2006 to 2009
$1.1M
NCI NIH HHS R01 CA120480NCI NIH HHS R01 CA153023NCI NIH HHS U54 CA151838
6 · The paper itself

Abstract

Near-infrared (NIR) fluorescent nanostructured materials have emerged as novel contrast agents for non-invasive bioimaging. Here we report a class of polymer-silica nanoparticles doped with a NIR fluorescent dye prepared through a facile one-pot strategy. Hydrophobic NIR fluorescent dyes such as IR 780 iodide could be easily encapsulated into the micellar core by self-assembly of amphiphilic triblock copolymer Pluronic F127. When subsequently adding silane in aqueous solution, nanoparticles with a cross-linked core and a hydrophilic PEG shell were formed. The structure of the as-obtained nanoparticles was confirmed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The nanoparticles exhibited a well-defined spherical structure with a mean diameter of approximately 30 nm, and excellent monodispersity and stability in aqueous solution. In addition, the photo-stability of IR 780 was significantly improved by encapsulation into the nanoparticles.

Identifiers

PMID28944057
PMCPMC5609720

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.