Evidence map›Paper›PMID 28943930›Full record

ArticleOncology letters2017

Downregulation of cytochrome

Tomoko Takesue, Hirofumi Kawakubo, Tetsu Hayashida, Mai Tsutsui, Kazuhiro Miyao, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Hiroya Takeuchi and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Tomoko TakesueDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Hirofumi KawakuboDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Tetsu HayashidaDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Mai TsutsuiDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Kazuhiro MiyaoDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Kazumasa FukudaDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Rieko NakamuraDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Tsunehiro TakahashiDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Norihito WadaDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Hiroya TakeuchiDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160-8582, Japan.
Keio University · JPKeio University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Comprehensive gene screening with transposons is a novel procedure for the systematic identification of resistant genes. The present study aimed to use this technique to identify candidate radioresistant genes in esophageal squamous cell carcinoma. A transposon is a base sequence that can translocate to another location in the genome at random. By inserting the cytomegalovirus promotor as a transcriptional activator in the transposon, the following gene in the new location becomes overexpressed and the gene located at the transposon insertion site is downregulated. Consequently, various transposon-tagged cells, which have differentially overexpressed or downregulated genes using the transposon method can be obtained. Following the irradiation of transposon-tagged cells, candidate radioresistant genes can be selected in order to detect the location of the transposon in the cells that have survived. A total of 11 genes were detected as candidate radioresistant genes. Cytochrome

Indexed as

cytochrome c oxidase 1esophageal cancergene screeningradioresistancetransposon

Identifiers

PMID28943930
PMCPMC5604182
OpenAlexW2741996499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.