ArticleOncology letters2017
Metastasis-associated in colon cancer 1: A promising biomarker for the metastasis and prognosis of colorectal cancer.
Article in Oncology letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Dual-mechanism of phytochemicals in cancer therapy: synergistic anti-angiogenic potency in cancer and proangiogenic impact against chemotherapy-induced cytotoxicity in vital organs.Frontiers in pharmacology · 2026Review
- Innovative Therapeutic Delivery of Metastasis-Associated in Colon Cancer 1-Suppressing miRNA Using High Transmembrane 4 L6 Family Member 5-Targeting Exosomes in Colorectal Cancer Mouse Models.International journal of molecular sciences · 2024Article
- Studies on the mechanism of local and extra-intestinal tissue manifestations in AOM-DSS-induced carcinogenesis in BALB/c mice: role of PARP-1, NLRP3, and autophagy.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- The impacts ofJournal of Cancer · 2023Article
- Article
- Aspirin sensitivity of PIK3CA-mutated Colorectal Cancer: potential mechanisms revisited.Cellular and molecular life sciences : CMLS · 2022Review
- High expression of FABP4 in colorectal cancer and its clinical significance.Journal of Zhejiang University. Science. B · 2021Article
- Genetic Variants ofInternational journal of molecular sciences · 2021Article
- Clinical Significance and Oncogenic Activity of GRWD1 Overexpression in the Development of Colon Carcinoma.OncoTargets and therapy · 2021Article
- Association of MACC1 expression with lymphatic metastasis in colorectal cancer: A nested case-control study.PloS one · 2021Article
- Effects ofJournal of Cancer · 2020Article
- miR-338-3p regulates the proliferation, apoptosis and migration of SW480 cells by targeting MACC1.Experimental and therapeutic medicine · 2019Article
- Clinical significance of MACC1, Twist1, and KAI1 expressions in infiltrating urothelial carcinoma of the bladder.International journal of clinical and experimental pathology · 2019Article
- The Significance of Serum S100A9 and TNC Levels as Biomarkers in Colorectal Cancer.Journal of Cancer · 2019Article
- IL-9 Exerts Antitumor Effects in Colon Cancer and Transforms the Tumor MicroenvironmentTechnology in cancer research & treatment · 2019Article
- DBC1 regulates Wnt/β-catenin-mediated expression of MACC1, a key regulator of cancer progression, in colon cancer.Cell death & disease · 2018Article
- Article
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4 authors.
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Abstract
Colorectal cancer (CRC) is the fourth most frequent type of malignancy in the world. Metastasis accounts for >90% mortalities in patients with CRC. The metastasis-associated in colon cancer 1 (MACC1) gene has been identified as a novel biomarker for the prediction of metastasis and disease prognosis, particularly for patients with early-stage disease. Previous clinical studies demonstrated that MACC1 expression and polymorphisms in CRC tissues were indicators of metastasis, and that circulating transcripts in plasma were also significantly associated with the survival of patients. The present review describes the use of MACC1 beyond its utility in the clinic. By elucidating the upstream and downstream signal pathways of MACC1, the well-known mechanisms of MACC1-mediated cell proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) are summarized, as well as the potential signaling pathways. Furthermore, the underlying mechanisms by which the overexpression of MACC1 causes cisplatin resistance are emphasized.
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