Evidence map›Paper›PMID 28943667›Full record

ArticleTetrahedron letters2017

Conversion of Methyl Ketones and Methyl Sulfones into α-Deutero-α,α-Difluoromethyl Ketones and α-Deutero-α,α-Difluoromethyl Sulfones in Three Synthetic Steps.

Munia F Sowaileh, Changho Han, Robert A Hazlitt, Eun Hoo Kim, Jinu P John, David A Colby

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Generation of formaldehyde and formaldehyde-dChemical communications (Cambridge, England) · 2022
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Munia F SowailehDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi, 38677, USA.
Changho HanDepartment of Biochemistry, Vanderbilt University, Nashville, Tennessee, 37232, USA.
Robert A HazlittDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi, 38677, USA.
Eun Hoo KimDepartment of Chemistry and Physical Sciences, Methodist University, Fayetteville, North Carolina, 28311, USA.
Jinu P JohnDSM Chemicals, Frankfort, Indiana, 46401, USA.
David A ColbyDepartment of BioMolecular Sciences, University of Mississippi, University, Mississippi, 38677, USA.

Funding

Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)P20GM104932 · NIGMS · UNIVERSITY OF MISSISSIPPI · PI MAJUMDAR, SOUMYAJIT · 2012 to 2016
$10.0M
Anthocyanins Derivatives for Drug Discovery in Aging Neurodegenerative DisordersR21AG039718 · NIA · PURDUE UNIVERSITY · PI COLBY, DAVID A · 2011 to 2012
$335k
NIA NIH HHS R21 AG039718NIGMS NIH HHS P20 GM104932
6 · The paper itself

Abstract

Deuterodifluoromethyl ketones and sulfones were assembled in three synthetic steps from methyl ketones and sulfones, respectively. The key synthetic transformation is the deuteration of the difluorocarbanion generated by the release of trifluoroacetate from highly α-fluorinated gem-diols. High levels of deuterium on the "CF

Indexed as

basedeuterationenolatefluorineketones

Identifiers

PMID28943667
PMCPMC5608106

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.