ArticleNature communications2017
The brain is required for normal muscle and nerve patterning during early Xenopus development.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
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- From the Microbiome to the Electrome: Implications for the Microbiota-Gut-Brain Axis.International journal of molecular sciences · 2024Article
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- Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain.iScience · 2023Article
- Bioelectric networks: the cognitive glue enabling evolutionary scaling from physiology to mind.Animal cognition · 2023Review
- Recent advances in 3D printable conductive hydrogel inks for neural engineering.Nano convergence · 2023Review
- A Novel Perspective on Neuronal Control of Anatomical Patterning, Remodeling, and Maintenance.International journal of molecular sciences · 2023Review
- Unusual Mathematical Approaches Untangle Nervous Dynamics.Biomedicines · 2022Review
- Advancing models of neural development with biomaterials.Nature reviews. Neuroscience · 2021Review
- Nervous system and tissue polarity dynamically adapt to new morphologies in planaria.Developmental biology · 2020Article
- Toward Decoding Bioelectric Events in Xenopus Embryogenesis: New Methodology for Tracking Interplay Between Calcium and Resting Potentials In Vivo.Journal of molecular biology · 2020Article
- HCN2 Channel-Induced Rescue of Brain TeratogenesisFrontiers in cellular neuroscience · 2020Article
- An in vivo brain-bacteria interface: the developing brain as a key regulator of innate immunity.NPJ Regenerative medicine · 2020Article
- Does regeneration recapitulate phylogeny? Planaria as a model of body-axis specification in ancestral eumetazoa.Communicative & integrative biology · 2020Article
- Preventing Ethanol-Induced Brain and Eye Morphology Defects Using Optogenetics.Bioelectricity · 2019Article
- Bioelectrical controls of morphogenesis: from ancient mechanisms of cell coordination to biomedical opportunities.Current opinion in genetics & development · 2019Review
- The Cognitive Lens: a primer on conceptual tools for analysing information processing in developmental and regenerative morphogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Review
- Neural control of body-plan axis in regenerating planaria.PLoS computational biology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Possible roles of brain-derived signals in the regulation of embryogenesis are unknown. Here we use an amputation assay in Xenopus laevis to show that absence of brain alters subsequent muscle and peripheral nerve patterning during early development. The muscle phenotype can be rescued by an antagonist of muscarinic acetylcholine receptors. The observed defects occur at considerable distances from the head, suggesting that the brain provides long-range cues for other tissue systems during development. The presence of brain also protects embryos from otherwise-teratogenic agents. Overexpression of a hyperpolarization-activated cyclic nucleotide-gated ion channel rescues the muscle phenotype and the neural mispatterning that occur in brainless embryos, even when expressed far from the muscle or neural cells that mispattern. We identify a previously undescribed developmental role for the brain and reveal a non-local input into the control of early morphogenesis that is mediated by neurotransmitters and ion channel activity.Functions of the embryonic brain prior to regulating behavior are unclear. Here, the authors use an amputation assay in Xenopus laevis to demonstrate that removal of the brain early in development alters muscle and peripheral nerve patterning, which can be rescued by modulating bioelectric signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.