ArticleInternal medicine (Tokyo, Japan)2018
Cholesterol Crystal Embolism Induced by Direct Factor Xa Inhibitor: A First Case Report.
Article in Internal medicine (Tokyo, Japan), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 12 citations in OpenAlex.
- Cholesterol crystal embolization syndrome: Systemic and end-organ injury.American heart journal plus : cardiology research and practice · 2025Article
- The Controversial Role of Glucocorticoids in Atheroembolic Renal Disease: A Narrative Review.Journal of clinical medicine · 2024Review
- Spontaneous Cholesterol Embolism Leading to Small Bowel Obstruction and Perforation.JACC. Case reports · 2023Article
- A case of acute renal injury and renal artery stenosis caused by cholesterol crystal embolization after coronary stenting: Improved by a combination therapy.Chronic diseases and translational medicine · 2021Article
- Ultramorphological analysis of plaque advancement and cholesterol crystal formation in Ldlr knockout mouse atherosclerosis.Atherosclerosis · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An 80-year-old man presented at our hospital with renal failure. He had been treated with edoxaban, an oral direct factor Xa inhibitor, for deep vein thrombosis for 10 months prior to admission. Although the pulses in his bilateral pedal arteries were palpable, cyanosis was present in the bilateral toes. Laboratory data indicated azotemia and eosinophilia. A skin biopsy confirmed a diagnosis of cholesterol crystal embolism (CCE). Because no invasive vascular procedure was performed, we assumed that CCE was related to edoxaban. To the best of our knowledge, this is the first case report suggesting CCE induced by an Xa inhibitor.
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