Trial reportThe Journal of allergy and clinical immunology2018
Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children.
Registry-linked trialOpen access · greenAbstract readClinical TrialLetter
In one paragraph
Trial report in The Journal of allergy and clinical immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03694158 (Effect of IL-4RαR576 Polymorphism on Response to Dupilumab in Asthma, a Genotype-stratified, Randomized, Placebo- Controlled Trial), which is not on this map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT03694158 phase4active not recruitingnot on this mapstarted 2021, after this paper: background citation
Effect of IL-4RαR576 Polymorphism on Response to Dupilumab in Asthma, a Genotype-stratified, Randomized, Placebo- Controlled Trial
Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Recommendations for Clinicians to Combat Environmental Disparities in Pediatric Asthma: A Review.Chest · 2024Review
- Genetic and environmental interactions contribute to immune variation in rewilded mice.Nature immunology · 2024Article
- Future of biologics in pediatric asthma: Optimizing response, early introduction, and equitable access to treatment.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- High plasma IL-6 levels may enhance the adverse effects of mouse allergen exposure in urban schools on asthma morbidity in children.The Journal of allergy and clinical immunology · 2023Article
- Genetic and Environmental interactions contribute to immune variation in rewilded mice.bioRxiv : the preprint server for biology · 2023Article
- The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice.The Journal of allergy and clinical immunology · 2023Article
- Environmental justice and allergic disease: A Work Group Report of the AAAAI Environmental Exposure and Respiratory Health Committee and the Diversity, Equity and Inclusion Committee.The Journal of allergy and clinical immunology · 2023Article
- Article
- Inborn Errors of the Immune System Associated With Atopy.Frontiers in immunology · 2022Review
- Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.Clinics in chest medicine · 2020Review
- Dupilumab to Treat Type 2 Inflammatory Diseases in Children and Adolescents.Paediatric drugs · 2020Review
- The Impact of Ambient Environmental Exposures to Microbial Products on Asthma Outcomes from Birth to Childhood.Current allergy and asthma reports · 2019Review
- The Effects of the Environment on Asthma Disease Activity.Immunology and allergy clinics of North America · 2019Review
- Inner-City Asthma in Children.Clinical reviews in allergy & immunology · 2019Review
- School exposure and asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Peggy S LaiDivision of Pulmonary and Critical Care, Massachusetts General Hospital, Boston, Mass; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass; Harvard Medical School, Boston, Mass.
Amir H MassoudHarvard Medical School, Boston, Mass; Allergy and Immunology, Boston Children's Hospital, Boston, Mass.
Mingcan XiaHarvard Medical School, Boston, Mass; Allergy and Immunology, Boston Children's Hospital, Boston, Mass.
Carter R PettyInstitutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Mass.
Amparito CunninghamHarvard Medical School, Boston, Mass.
Talal A ChatilaHarvard Medical School, Boston, Mass; Allergy and Immunology, Boston Children's Hospital, Boston, Mass.
Wanda PhipatanakulHarvard Medical School, Boston, Mass; Allergy and Immunology, Boston Children's Hospital, Boston, Mass. Electronic address: wanda.phipatanakul@childrens.harvard.edu.
Harvard University · USBoston Children's Hospital · US
Funding
Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2MTranslational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6MControlling and preventing Asthma progression and Severity in Kids (CASK)U01AI126614 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2016 to 2023
$21.0MMOLECULAR BASIS OF ALLERGIC AND IMMUNOLOGIC DISEASET32AI007512 · NIAID · CHILDREN'S HOSPITAL BOSTON · PI Janet Chou, Peter A Nigrovic · 1996 to 2026
$13.1MMolecular Basis of Hyper lgE ImmunodeficiencyR01AI065617 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Talal Amine Chatila · 2006 to 2026
$10.9MSICAS- Diversity SupplementU01AI110397 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2015 to 2020
$8.8MEffect of IL-4RαR576 variant on response to Dupilumab in children with AsthmaU01AI143514 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI CHATILA, TALAL AMINE, PHIPATANAKUL, WANDA · 2019 to 2023
$8.4MALLERGENS IN INNER-CITY SCHOOLS AND CHILDHOOD ASTHMAR01AI073964 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2008 to 2012
$4.6MEnvironmental Risk Factors for Pediatric Sleep Disordered BreathingR01HL137192 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2017 to 2020
$3.5MMidcareer Investigator Award: Urban School Allergen Exposures and Childhood AsthmK24AI106822 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PHIPATANAKUL, WANDA · 2013 to 2022
$1.9MEndotoxin, the airway transcriptome, and obstructive lung diseaseK23ES023700 · NIEHS · MASSACHUSETTS GENERAL HOSPITAL · PI LAI, PEGGY SUE · 2013 to 2017
$764kNCATS NIH HHS UL1 TR001102NHLBI NIH HHS R01 HL137192NIAID NIH HHS K24 AI106822NIAID NIH HHS R01 AI065617NIAID NIH HHS R01 AI073964NIAID NIH HHS T32 AI007512NIAID NIH HHS U01 AI110397NIAID NIH HHS U01 AI126614NIAID NIH HHS U01 AI143514NIEHS NIH HHS K23 ES023700NIEHS NIH HHS P30 ES000002
Abstract
PubMed holds no abstract for this paper.
Indexed as
AsthmaEnvironmental ExposureGene-Environment InteractionPolymorphism, GeneticSchoolsUrban PopulationChildEndotoxinsFemaleHumansInterleukin-4 Receptor alpha SubunitMaleProspective StudiesEndotoxinsIL4R protein, humanInterleukin-4 Receptor alpha Subunit
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT03694158ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.