ArticleBiochimica et biophysica acta. General subjects2017
Effect of chaotropes on the kinetics of iron release from ferritin by flavin nucleotides.
Article in Biochimica et biophysica acta. General subjects, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Ferroptosis: iron release mechanisms in the bioenergetic process.Cancer metastasis reviews · 2025Review
- Ferritin nanocages as efficient nanocarriers and promising platforms for COVID-19 and other vaccines development.Biochimica et biophysica acta. General subjects · 2023Review
- Effect of Phosphate and Ferritin Subunit Composition on the Kinetics, Structure, and Reactivity of the Iron Core in Human Homo- and Heteropolymer Ferritins.Biochemistry · 2022Article
- Iron Mobilization from Ferritin in Yeast Cell Lysate and Physiological Implications.International journal of molecular sciences · 2022Article
- Structural Insights for the Stronger Ability of Shrimp Ferritin to Coordinate with Heavy Metal Ions as Compared to Human H-Chain Ferritin.International journal of molecular sciences · 2021Article
- Mutant L-chain ferritins that cause neuroferritinopathy alter ferritin functionality and iron permeability.Metallomics : integrated biometal science · 2019Article
- Ferritin exhibits Michaelis-Menten behavior with oxygen but not with iron during iron oxidation and core mineralization.Metallomics : integrated biometal science · 2019Article
- Iron, Ferritin, Hereditary Ferritinopathy, and Neurodegeneration.Frontiers in neuroscience · 2019Review
- Reductive Mobilization of Iron from Intact Ferritin: Mechanisms and Physiological Implication.Pharmaceuticals (Basel, Switzerland) · 2018Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundFerritins are ubiquitous multi-subunit iron storage and detoxification proteins that play a critical role in iron homeostasis. Ferrous ions that enter the protein's shell through hydrophilic channels are rapidly oxidized at dinuclear centers on the H-subunit before transfer to the protein's cavity for storage. The mechanisms of iron loading have been extensively studied, but little is known about iron mobilization. Fe(III) reduction can occur via rapid reduction by suitable reducing agents followed by chelation of Fe(II) ions or via direct and slow Fe(III) chelation. Here, the iron release kinetics from ferritin by FMNH
methodsThe iron release kinetics from horse and human ferritins by FMNH RESULTS AND
conclusionsUnder our experimental conditions, iron reductive mobilization by the non-enzymatic FMN/NAD(P)H system is limited by the concentration of FMNH GENERAL SIGNIFICANCE: Caution must be exercised when interpreting the kinetics of iron mobilization from ferritin using the FMN/NAD(P)H system. The kinetics are highly dependent on the amount of dissolved oxygen and the concentration of reagents used.
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