ArticleStem cell reports2017
Vitamin C-Induced Epigenetic Modifications in Donor NSCs Establish Midbrain Marker Expressions Critical for Cell-Based Therapy in Parkinson's Disease.
Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Integration of Metabolic Pathways and Micronutrient Signals Influences Neurodevelopment by Modulating Neural Stem Cell Dynamics.Molecular neurobiology · 2026Review
- Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs-Derived Neuronal Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The Neuroanatomy of Induced Pluripotent Stem Cells: In Vitro Models of Subcortical Nuclei in Neurodegenerative Disorders.Current issues in molecular biology · 2024Review
- Beneficial Effects ofNutrients · 2024Review
- Modifications on histone tails in Parkinson's disease.SciBase neurology · 2024Article
- Epigenetic Regulators of DNA Cytosine Modification: Promising Targets for Cancer Therapy.Biomedicines · 2023Review
- Vitamin B12 Ameliorates the Pathological Phenotypes of Multiple Parkinson's Disease Models by Alleviating Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Article
- Role of vitamin C and SVCT2 in neurogenesis.Frontiers in neuroscience · 2023Review
- Integrating nutriepigenomics in Parkinson's disease management: New promising strategy in the omics era.IBRO neuroscience reports · 2022Article
- Adipose tissue derived stromal cells in a gelatin-based 3D matrix with exclusive ascorbic acid signalling emerged as a novel neural tissue engineering construct: an innovative prototype for soft tissue.Regenerative biomaterials · 2022Article
- SVCT2 Overexpression and Ascorbic Acid Uptake Increase Cortical Neuron Differentiation, Which Is Dependent on Vitamin C Recycling between Neurons and Astrocytes.Antioxidants (Basel, Switzerland) · 2021Article
- Neurodevelopmental defects and neurodegenerative phenotypes in human brain organoids carrying Parkinson's disease-linkedScience advances · 2021Article
- Epigenetic Regulation of Genomic Stability by Vitamin C.Frontiers in genetics · 2021Review
- Vitamin C Recycling Regulates Neurite Growth in Neurospheres Differentiated In Vitro.Antioxidants (Basel, Switzerland) · 2020Article
- Chromatin-modifying drugs and metabolites in cell fate control.Cell proliferation · 2020Review
- Cell therapy for Parkinson's disease is coming of age: current challenges and future prospects with a focus on immunomodulation.Gene therapy · 2020Review
- A balanced evaluation of the evidence for adult neurogenesis in humans: implication for neuropsychiatric disorders.Brain structure & function · 2019Review
- Epigenetics of the Synapse in Neurodegeneration.Current neurology and neuroscience reports · 2019Review
- Epigenetic Analysis in Human Neurons: Considerations for Disease Modeling in PD.Frontiers in neuroscience · 2019Article
- SVCT2 Promotes Neural Stem/Progenitor Cells Migration Through Activating CDC42 After Ischemic Stroke.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cultured neural stem/precursor cells (NSCs) are regarded as a potential systematic cell source to treat Parkinson's disease (PD). However, the therapeutic potential of these cultured NSCs is lost during culturing. Here, we show that treatment of vitamin C (VC) enhances generation of authentic midbrain-type dopamine (mDA) neurons with improved survival and functions from ventral midbrain (VM)-derived NSCs. VC acted by upregulating a series of mDA neuron-specific developmental and phenotype genes via removal of DNA methylation and repressive histone code (H3K9m3, H3K27m3) at associated gene promoter regions. Notably, the epigenetic changes induced by transient VC treatment were sustained long after VC withdrawal. Accordingly, transplantation of VC-treated NSCs resulted in improved behavioral restoration, along with enriched DA neuron engraftment, which faithfully expressed midbrain-specific markers in PD model rats. These results indicate that VC treatment to donor NSCs could be a simple, efficient, and safe therapeutic strategy for PD in the future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.