Evidence map›Paper›PMID 28943228›Full record

Trial reportEBioMedicine2017

Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial.

R F Slykerman, F Hood, K Wickens, J M D Thompson, C Barthow, R Murphy, J Kang, J Rowden, P Stone, J Crane and 6 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03494725 (Proof-of-Concept "Stress & Anxiety Dampening Effects of Lpc-37"), which is not on this map. Cited by 208 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03494725 nacompletednot on this mapstarted 2018, after this paper: background citation

Proof-of-Concept "Stress & Anxiety Dampening Effects of Lpc-37"

TypeinterventionalSponsorDaacroRan2018 to 2018Enrolled120ConditionsHealthy, Stress, PsychologicalArmsLpc-37, Placebo
3 · Its place in the literature

Who cites it

208 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  8. Probiotics for the treatment of depression and its comorbidities: A systemic review.Frontiers in cellular and infection microbiology · 2023
    Pooled it
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  15. Trial
  16. The Impact ofNutrients · 2025
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  19. Effects ofNutrients · 2024
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148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

R F SlykermanDepartment of Paediatrics: Child and Youth Health, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
F HoodDepartment of Medicine, University of Otago, P O Box 7343, Wellington, New Zealand.
K WickensDepartment of Medicine, University of Otago, P O Box 7343, Wellington, New Zealand.
J M D ThompsonDepartment of Paediatrics: Child and Youth Health, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
C BarthowDepartment of Medicine, University of Otago, P O Box 7343, Wellington, New Zealand.
R MurphyDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
J KangDepartment of Medicine, University of Otago, P O Box 7343, Wellington, New Zealand.
J RowdenDepartment of Paediatrics: Child and Youth Health, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
P StoneDepartment of Obstetrics and Gynaecology, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand.
J CraneDepartment of Medicine, University of Otago, P O Box 7343, Wellington, New Zealand.
T StanleyDepartment of Paediatrics, University of Otago, P O Box 7343, Wellington, New Zealand.
P AbelsDepartment of Medicine, University of Otago, P O Box 7343, Wellington, New Zealand.
G PurdieDean's Office, University of Otago, P O Box 7343, Wellington, New Zealand.
R MaudeGraduate School of Nursing, Midwifery, and Health, Victoria University of Wellington, PO Box 600, Wellington 6140, New Zealand.
E A MitchellDepartment of Paediatrics: Child and Youth Health, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. Electronic address: e.mitchell@auckland.ac.nz.
Probiotic in Pregnancy Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundProbiotics may help to prevent symptoms of anxiety and depression through several putative mechanisms.

objectiveThe aim of this study was to evaluate the effect of Lactobacillus rhamnosus HN001 (HN001) given in pregnancy and postpartum on symptoms of maternal depression and anxiety in the postpartum period. This was a secondary outcome, the primary outcome being eczema in the offspring at 12months of age. DESIGN, SETTING,

participantsA randomised, double-blind, placebo-controlled trial of the effect of HN001 on postnatal mood was conducted in 423 women in Auckland and Wellington, New Zealand. Women were recruited at 14-16weeks gestation.

interventionWomen were randomised to receive either placebo or HN001 daily from enrolment until 6months postpartum if breastfeeding. OUTCOME MEASURES: Modified versions of the Edinburgh Postnatal Depression Scale and State Trait Anxiety Inventory were used to assess symptoms of depression and anxiety postpartum.

trial registrationAustralia NZ Clinical Trials Registry: ACTRN12612000196842.

findings423 women were recruited between December 2012 and November 2014. 212 women were randomised to HN001 and 211 to placebo. 380 women (89.8%) completed the questionnaire on psychological outcomes, 193 (91.0%) in the treatment group and 187 (88.6%) in the placebo group. Mothers in the probiotic treatment group reported significantly lower depression scores (HN001 mean=7·7 (SD=5·4), placebo 9·0 (6·0); effect size -1·2, (95% CI -2·3, -0·1), p=0·037) and anxiety scores (HN001 12·0 (4·0), placebo 13·0 (4·0); effect size -1·0 (-1·9, -0·2), p=0·014) than those in the placebo group. Rates of clinically relevant anxiety on screening (score>15) were significantly lower in the HN001 treated mothers (OR=0·44 (0·26, 0·73), p=0·002).

interpretationWomen who received HN001 had significantly lower depression and anxiety scores in the postpartum period. This probiotic may be useful for the prevention or treatment of symptoms of depression and anxiety postpartum. FUNDING SOURCE: Health Research Council of New Zealand (11/318) and Fonterra Co-operative Group Ltd.

Indexed as

AdultAnxietyDepression, PostpartumDouble-Blind MethodFemaleHumansLacticaseibacillus rhamnosusMaleMaternal Nutritional Physiological PhenomenaNew ZealandPregnancyProbioticsTreatment OutcomeAnxietyDepressionMicrobiome-gut-brain axisProbioticRandomised controlled trial

Identifiers

PMID28943228
PMCPMC5652021

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.