ArticleCurrent biology : CB2017
Genome Architecture and Evolution of a Unichromosomal Asexual Nematode.
Article in Current biology : CB, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 76 citations in OpenAlex.
- Stepwise emergence of recombination suppression precedes fissiparous asexuality in the planarian Schmidtea mediterranea.Nature communications · 2026Article
- Genome evolution in parthenogenetic nematodes shaped by chromosome rearrangements and introgression.Genome research · 2026Article
- Origins of Self-Fertility in ThreeBiology · 2026Review
- Argonautes and small RNAs associated with nematode programmed DNA elimination.bioRxiv : the preprint server for biology · 2025Article
- Gain and Loss of Heterozygosity in the Genome of the Asexual Nematode Halicephalobus mephisto.Journal of molecular evolution · 2025Article
- Article
- Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in a subterrestrial metazoan, Halicephalobus mephisto.Communications biology · 2024Article
- Maternal inheritance of functional centrioles in two parthenogenetic nematodes.Nature communications · 2024Article
- Comparative genomics of the closely related fungal genera Cryptococcus and Kwoniella reveals karyotype dynamics and suggests evolutionary mechanisms of pathogenesis.PLoS biology · 2024Article
- Chromosome fusion and programmed DNA elimination shape karyotypes of nematodes.Current biology : CB · 2024Article
- Unzipped genome assemblies of polyploid root-knot nematodes reveal unusual and clade-specific telomeric repeats.Nature communications · 2024Article
- Comparative genomics ofbioRxiv : the preprint server for biology · 2024Article
- Biotic interactions between the human pathogen Legionella pneumophila and nematode grazers in cooling tower biofilms.PloS one · 2024Article
- A catalogue of chromosome counts for Phylum Nematoda.Wellcome open research · 2024Article
- Comparative Genomics of Sex, Chromosomes, and Sex Chromosomes in Caenorhabditis elegans and Other Nematodes.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Chromosome fusion and programmed DNA elimination shape karyotypes of parasitic nematodes.bioRxiv : the preprint server for biology · 2023Article
- Evolution of a biological thermocouple by adaptation of cytochrome c oxidase in a subterrestrial metazoan.bioRxiv : the preprint server for biology · 2023Article
- Phylloxera and Aphids Show Distinct Features of Genome Evolution Despite Similar Reproductive Modes.Molecular biology and evolution · 2023Article
- Unraveling the Unusual Subgenomic Organization in the Neopolyploid Free-Living Flatworm Macrostomum lignano.Molecular biology and evolution · 2023Article
- Unzipped chromosome-level genomes reveal allopolyploid nematode origin pattern as unreduced gamete hybridization.Nature communications · 2023Article
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11 authors at 3 institutions in 2 countries.
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Abstract
Asexual reproduction in animals, though rare, is the main or exclusive mode of reproduction in some long-lived lineages. The longevity of asexual clades may be correlated with the maintenance of heterozygosity by mechanisms that rearrange genomes and reduce recombination. Asexual species thus provide an opportunity to gain insight into the relationship between molecular changes, genome architecture, and cellular processes. Here we report the genome sequence of the parthenogenetic nematode Diploscapter pachys with only one chromosome pair. We show that this unichromosomal architecture is shared by a long-lived clade of asexual nematodes closely related to the genetic model organism Caenorhabditis elegans. Analysis of the genome assembly reveals that the unitary chromosome arose through fusion of six ancestral chromosomes, with extensive rearrangement among neighboring regions. Typical nematode telomeres and telomeric protection-encoding genes are lacking. Most regions show significant heterozygosity; homozygosity is largely concentrated to one region and attributed to gene conversion. Cell-biological and molecular evidence is consistent with the absence of key features of meiosis I, including synapsis and recombination. We propose that D. pachys preserves heterozygosity and produces diploid embryos without fertilization through a truncated meiosis. As a prelude to functional studies, we demonstrate that D. pachys is amenable to experimental manipulation by RNA interference.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.