ArticleMayo Clinic proceedings2017
Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population.
Article in Mayo Clinic proceedings, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Genome-Wide Interaction Analyses of Serum Calcium on Ventricular Repolarization Time in 125 393 Participants.Journal of the American Heart Association · 2024Pooled it
- Long-Term Efficacy and Safety of Upacicalcet in Japanese Hemodialysis Patients with Secondary Hyperparathyroidism: Open-Label 52-Week Study.American journal of nephrology · 2025Trial
- First-in-Patient Phase I/II Study of Upacicalcet in Japanese Patients with Secondary Hyperparathyroidism Undergoing Hemodialysis: Pharmacokinetic and Pharmacodynamic Properties.Clinical pharmacokinetics · 2022Trial
- Low serum calcium is associated with higher long-term mortality in myocardial infarction patients from a population-based registry.Scientific reports · 2021Trial
- Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2026Review
- Association between serum calcium concentration in patients with osteoarthritis and all-cause mortality and cardiovascular mortality: a retrospective cohort study.Journal of health, population, and nutrition · 2026Article
- Study of plasma essential element concentrations to explore markers of acute myocardial infarction.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Seeking a Treatable Cause of Out-of-Hospital Cardiac Arrest during and after Resuscitation.Journal of clinical medicine · 2024Review
- Serum calcium is associated with sudden cardiac arrest in stroke patients from ICU: a multicenter retrospective study based on the eICU collaborative research database.Scientific reports · 2024Article
- The Prognostic Value of Serum Calcium Levels in Elderly Dilated Cardiomyopathy Patients.Global heart · 2024Article
- Adjunctive Therapeutics in the Management of Cardiopulmonary Resuscitation: A Narrative Literature Review.Journal of clinical medicine · 2023Review
- Development and Validation of a Personalized Model With Transfer Learning for Acute Kidney Injury Risk Estimation Using Electronic Health Records.JAMA network open · 2022Article
- Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.Communications biology · 2022Article
- L-shaped association of serum calcium with all-cause and CVD mortality in the US adults: A population-based prospective cohort study.Frontiers in nutrition · 2022Article
- Association of serum calcium levels with infarct volume and stroke scores in acute ischemic stroke patients: An observational study.Caspian journal of internal medicine · 2022Article
- The Predictive Value of Serum Calcium on Heart Rate Variability and Cardiac Function in Type 2 Diabetes Patients.Frontiers in endocrinology · 2022Article
- Sequelae and Comorbidities of COVID-19 Manifestations on the Cardiac and the Vascular Systems.Frontiers in physiology · 2021Review
- Manifestations of left ventricular dysfunction and arrhythmia in patients with chronic hypoparathyroidism and pseudohypoparathyroidism: a preliminary study.BMC endocrine disorders · 2020Article
- The Incidence and Associated Factors of Sudden Death in Patients on Hemodialysis: 10-Year Outcome of the Q-Cohort Study.Journal of atherosclerosis and thrombosis · 2020Article
- Dynamic thiol/disulfide homeostasis and oxidant status in patients with hypoparathyroidism.Journal of medical biochemistry · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate the potential role of low serum Ca levels in the occurrence of sudden cardiac arrest (SCA) in the community. PATIENTS AND
methodsWe compared 267 SCA cases [177 (66%) men] and 445 controls [314 (71%) men] from a large population-based study (catchment population ∼1 million individuals) in the US Northwest from February 1, 2002, through December 31, 2015. Patients were included if their age was 18 years or older with available creatinine clearance (CrCl) and serum electrolyte levels for analyses to enable adjustment for renal function. For cases, creatinine clearance and electrolyte levels were required to be measured within 90 days of the SCA event.
resultsCases of SCA had higher proportions of blacks [31 (12%) vs 14 (3%); P<.001], diabetes mellitus [122 (46%) vs 126 (28%); P<.001], and chronic kidney disease [102 (38%) vs 73 (16%); P<.001] than did controls. In multivariable logistic regression analysis, a 1-unit decrease in Ca levels was associated with a 1.6-fold increase in odds of SCA (odds ratio, 1.63; 95% CI, 1.06-2.51). Blood Ca levels lower than 8.95 mg/dL (to convert to mmol/L, multiply by 0.025) were associated with a 2.3-fold increase in odds of SCA as compared with levels higher than 9.55 mg/dL (odds ratio, 2.33; 95% CI, 1.17-4.61). Cases of SCA had significantly prolonged corrected QT intervals on the 12-lead electrocardiogram than did controls (465±37 ms vs 425±33 ms; P<.001).
conclusionLower serum Ca levels were independently associated with an increased risk of SCA in the community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.