Evidence map›Paper›PMID 28943011›Full record

ArticleJournal of vascular surgery2018

Early reintervention after open and endovascular abdominal aortic aneurysm repair is associated with high mortality.

Sarah E Deery, Thomas F X O'Donnell, Thomas C F Bodewes, Barbara A Dalebout, Alexander B Pothof, Katie E Shean, Jeremy D Darling, Marc L Schermerhorn

Registry-linked trialOpen access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of vascular surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04061798 (ACTION-1), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04061798 phase4terminatednot on this mapstarted 2020, after this paper: background citation

ACTION-1: ACT Guided Heparinization During Open Abdominal Aortic Aneurysm Repair, a Randomised Trial.

TypeinterventionalSponsorDijklander ZiekenhuisRan2020 to 2024Enrolled294ConditionsAbdominal Aortic Aneurysm, Surgery, Arterial DiseaseArmsACT guided heparinization, 5 000 IU of heparin
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Tailor-Made Tapering Grafts for Large-Neck Aorta.Annals of vascular diseases · 2022
    Article
  8. Analysis of Outcomes After Endovascular Abdominal Aortic Aneurysm Repair in Patients With Abnormal Findings on the First Postoperative Computed Tomography Angiography.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2021
    Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sarah E DeeryDivision of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Thomas F X O'DonnellDivision of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
Thomas C F BodewesDivision of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass.
Barbara A DaleboutDivision of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass.
Alexander B PothofDivision of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass.
Katie E SheanDivision of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass.
Jeremy D DarlingDivision of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass.
Marc L SchermerhornDivision of Vascular and Endovascular Surgery, Beth Israel Deaconess Medical Center, Boston, Mass. Electronic address: mscherm@bidmc.harvard.edu.
Hadassah Medical Center · ILBeth Israel Deaconess Medical Center · US

Funding

HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5M
NHLBI NIH HHS T32 HL007734
6 · The paper itself

Abstract

objectiveAlthough reinterventions are generally considered more common after endovascular aneurysm repair (EVAR) than after open surgical repair (OSR), less is known about reintervention in the early postoperative period. Furthermore, there are few data regarding the impact of early reintervention on 30-day mortality. We sought to evaluate the rates and types of reintervention after abdominal aortic aneurysm (AAA) repair and the impact of reintervention on postoperative mortality.

methodsThe American College of Surgeons National Surgical Quality Improvement Program (NSQIP) was queried from 2012 to 2014 for all intact, infrarenal AAA repairs. The 30-day reintervention was classified by Current Procedural Terminology (CPT) codes. Univariate analysis comparing patients with and without reintervention was performed with the Fisher exact test and Mann-Whitney U test. Logistic regression was used to identify predictors of reintervention and to assess the association between 30-day reintervention and mortality.

resultsWe identified 5877 patients (OSR, 658 [11%]; EVAR, 5219 [89%]), of whom 261 underwent reintervention (OSR, 7.1%; EVAR, 4.1%; P < .01). Patients who underwent reintervention had larger aortic diameter (median, 5.7 cm vs 5.5 cm; P < .01), were more often symptomatic at presentation (16% vs 9.1%; P < .01), and were more likely to have renal insufficiency (7.7% vs 3.6%; P < .01) and history of prior abdominal operations (32% vs 26%; P = .04). Patients who underwent reintervention had higher 30-day mortality (OSR, 28% vs 2.8% [P < .001]; EVAR, 12% vs 1.0% [P < .001]) and major complications. Factors significantly associated with reintervention included open repair, diameter, symptom status, hypertension, and renal insufficiency. After adjusting for demographics, comorbidities, and type of repair, reintervention was independently associated with 30-day mortality after EVAR and OSR (odds ratio, 13; 95% confidence interval, 8-22; P < .001).

conclusionsCompared with EVAR, patients undergoing open infrarenal AAA repair were significantly more likely to undergo 30-day reintervention, which could be related to higher open anatomic complexity and lower experience of the surgeon with open repair. Reintervention after both EVAR and OSR was associated with a >10-fold increase in postoperative mortality, emphasizing the need to minimize the complications associated with reintervention.

Indexed as

AgedAged, 80 and overAortic Aneurysm, AbdominalBlood Vessel Prosthesis ImplantationEndovascular ProceduresFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPostoperative ComplicationsRegistriesReoperationRisk Assessment

Identifiers

PMID28943011
PMCPMC5794651
OpenAlexW2757818372

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.