Evidence map›Paper›PMID 28942944›Full record

ArticleCellular immunology2017

Death Receptor 3 regulates distinct pathological attributes of acute versus chronic murine allergic lung inflammation.

Ravinder Kaur Singh, William Victor Perks, Jason Peter Twohig, Emma J Kidd, Kenneth Broadley, Stuart N Farrow, Anwen Sian Williams, Philip Russel Taylor, Eddie Chung Yern Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Crosstalk between ILC2s and Th2 CD4Journal of immunology research · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Ravinder Kaur SinghDivision of Infection & Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
William Victor PerksDivision of Infection & Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Jason Peter TwohigDivision of Infection & Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Emma J KiddSchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
Kenneth BroadleySchool of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3NB, UK.
Stuart N FarrowCRT discoveries laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
Anwen Sian WilliamsDivision of Infection & Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Philip Russel TaylorDivision of Infection & Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Eddie Chung Yern WangDivision of Infection & Immunity, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, UK. Electronic address: wangec@cf.ac.uk.
Cardiff University · GB

Funding

Medical Research Council G0901119Medical Research Council MR/J002151/1
6 · The paper itself

Abstract

The Death Receptor 3 (DR3)/Tumour Necrosis Factor-like cytokine 1A (TL1A) axis stimulates effector T cells and type 2 innate lymphocytes (ILC2) that trigger cytokine release and drive disease pathology in several inflammatory and autoimmune diseases, including murine models of acute allergic lung inflammation (ALI). The aim of this study was to elucidate the role of DR3 in chronic ALI compared to acute ALI, using mice genetically deficient in the DR3 gene (DR3

Indexed as

Acute DiseaseAnimalsCells, CulturedChronic DiseaseDisease ProgressionFemaleGoblet CellsHyperplasiaHypersensitivityImmunity, InnateLungLymphocytesMiceMice, Inbred C57BLMice, KnockoutPneumoniaReceptors, Tumor Necrosis Factor, Member 25Tnfrsf25 protein, mouse

Identifiers

PMID28942944
PMCPMC5736020
OpenAlexW2754317469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.