Evidence map›Paper›PMID 28942909›Full record

SynthesisPM & R : the journal of injury, function, and rehabilitation2017

A Systematic Review of Exercise Systematic Reviews in the Cancer Literature (2005-2017).

Nicole L Stout, Jennifer Baima, Anne K Swisher, Kerri M Winters-Stone, Judith Welsh

2 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PM & R : the journal of injury, function, and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 196 papers, 27 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
196citing papers in PubMed, 27 pooled it
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03500393 naterminatednot on this mapstarted 2018, after this paper: background citation

A Remotely Supervised Exercise Program for Lung Cancer Patients Undergoing Chemoradiation

TypeinterventionalSponsorDartmouth-Hitchcock Medical CenterRan2018 to 2021Enrolled4ConditionsLung CancerArmsRemotely Supervised Exercise (REM), Unsupervised Exercise (UNSUP)
NCT05349227 narecruitingnot on this mapstarted 2022, after this paper: background citation

Comprehensive Outcomes for After Cancer Health (COACH): the Feasibility and Impact of an MHealth Augmented Coaching Program for Self-Management in Cancer Survivors

TypeinterventionalSponsorPack HealthRan2022 to 2027Enrolled625ConditionsOvarian Cancer, Breast Cancer, Lung Cancer, Gastric CancerArmsDigital Health Coaching Program, Fitbit
3 · Its place in the literature

Who cites it

196 citing papers in PubMed, 27 syntheses or guidelines pooled it, 401 citations in OpenAlex.

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  3. Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  12. Physical rehabilitation for the management of cancer-related fatigue during cytotoxic treatment: a systematic review with meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  16. Lung Cancer and Self-Management Interventions: A Systematic Review of Randomised Controlled Trials.International journal of environmental research and public health · 2022
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136 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Nicole L StoutNational Institutes of Health, Clinical Center, Rehabilitation Medicine Department, Bethesda, MD(∗). Electronic address: Nicole.stout@nih.gov.
Jennifer BaimaUniversity of Massachusetts Memorial Health Care, Physical Medicine and Rehabilitation, Worcester, MA(†).
Anne K SwisherWest Virginia University, School of Medicine, Morgantown, WV(‡).
Kerri M Winters-StoneOregon Health and Science University, School of Nursing, Portland, OR(§).
Judith WelshNational Institutes of Health, NIH Library, Bethesda, MD(¶).
National Institutes of Health · USOregon Health & Science University · USUMass Memorial Health Care · USWest Virginia University · US

Funding

Preventing falls after cancer: Tai chi vs. strength trainingR01CA163474 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI WINTERS-STONE, KERRI M · 2012 to 2016
$3.0M
Intramural NIH HHS Z99 CL999999NCI NIH HHS R01 CA163474
6 · The paper itself

Abstract

backgroundEvidence supports the benefits of exercise for patients with cancer; however, specific guidance for clinical decision making regarding exercise timing, frequency, duration, and intensity is lacking. Efforts are needed to optimize clinical recommendations for exercise in the cancer population.

objectivesTo aggregate information regarding the benefit of exercise through a systematic review of existing systematic reviews in the cancer exercise literature. DATA SOURCES: PubMed, CINAHL Plus, Scopus, Web of Science, and EMBASE. STUDY ELIGIBILITY CRITERIA: Systematic reviews and meta-analyses of the impact of movement-based exercise on the adult cancer population.

methodsTwo author teams reviewed 302 abstracts for inclusion with 93 selected for full-text review. A total of 53 studies were analyzed. A Measurement Tool to Assess Systematic Reviews (AMSTAR) was used as a quality measure of the reviews. Information was extracted using the PICO format (ie, participants, intervention, comparison, outcomes). Descriptive findings are reported.

resultsMean AMSTAR score = 7.66/11 (±2.04) suggests moderate quality of the systematic reviews. Exercise is beneficial before, during, and after cancer treatment, across all cancer types, and for a variety of cancer-related impairments. Moderate-to-vigorous exercise is the best level of exercise intensity to improve physical function and mitigate cancer-related impairments. Therapeutic exercises are beneficial to manage treatment side effects, may enhance tolerance to cancer treatments, and improve functional outcomes. Supervised exercise yielded superior benefits versus unsupervised. Serious adverse events were not common. LIMITATIONS: Movement-based exercise intervention outcomes are reported. No analysis of pooled effects was calculated across reviews due to significant heterogeneity within the systematic reviews. Findings do not consider exercise in advanced cancers or pediatric populations.

conclusionsExercise promotes significant improvements in clinical, functional, and in some populations, survival outcomes and can be recommended regardless of the type of cancer. Although generally safe, patients should be screened and appropriate precautions taken. Efforts to strengthen uniformity in clinical trial reporting, develop clinical practice guidelines, and integrate exercise and rehabilitation services into the cancer delivery system are needed.

Indexed as

Continuity of Patient CareQuality of LifeDisease-Free SurvivalExerciseExercise TherapyFemaleHumansMaleNeoplasmsPhysical FitnessReview Literature as TopicRisk AssessmentSurvival AnalysisSurvivors

Identifiers

PMID28942909
PMCPMC5679711
OpenAlexW2760160481

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.