ArticleJournal of the American Academy of Child and Adolescent Psychiatry2017
Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Descriptions of Disordered Eating in German Psychiatric Textbooks, 1803-2017.Frontiers in psychiatry · 2020Pooled it
- An ARFID case report assessment with 18F-FDG PET/MRI and treatment with olanzapine, escitalopram and fluoxetine in adult.Frontiers in psychiatry · 2024Article
- Sex-specific association between prenatal androgenization (second-to-fourth digit length ratio) and frontal brain volumes in adolescents.European archives of psychiatry and clinical neuroscience · 2023Article
- Altered prefrontal activation during the inhibition of eating responses in women with bulimia nervosa.Psychological medicine · 2023Article
- Childhood maltreatment is associated with cortical thinning in people with eating disorders.European archives of psychiatry and clinical neuroscience · 2023Article
- Changes in cognitive and behavioral control after lamotrigine and intensive dialectical behavioral therapy for severe, multi-impulsive bulimia nervosa: an fMRI case study.Eating and weight disorders : EWD · 2022Article
- Structural brain differences in recovering and weight-recovered adult outpatient women with anorexia nervosa.Journal of eating disorders · 2021Article
- Subcortical brain volume and cortical thickness in adolescent girls and women with binge eating.The International journal of eating disorders · 2021Article
- Subclinical eating disorder traits are correlated with cortical thickness in regions associated with food reward and perception.Brain imaging and behavior · 2020Article
- Subcortical Shape Abnormalities in Bulimia Nervosa.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Cognitive Neuroscience of Eating Disorders.The Psychiatric clinics of North America · 2019Review
- Increased Functional Connectivity Between Ventral Attention and Default Mode Networks in Adolescents With Bulimia Nervosa.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Article
- Abnormal fronto-striatal activation as a marker of threshold and subthreshold Bulimia Nervosa.Human brain mapping · 2018Article
- Review
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Authors and funding
9 authors at 4 institutions in 3 countries.
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Abstract
objectiveCross-sectional data suggest functional and anatomical disturbances in inferior and orbital frontal regions in bulimia nervosa (BN). Using longitudinal data, we investigated whether reduced cortical thickness (CT) in these regions arises early and persists over adolescence in BN, independent of symptom remission, and whether CT reductions are markers of BN symptoms.
methodA total of 33 adolescent females with BN symptoms (BN or other specified feeding or eating disorder) and 28 healthy adolescents participated in this study. Anatomical magnetic resonance imaging and clinical data were acquired at 3 time points within 2-year intervals over adolescence, with 31% average attrition between assessments. Using a region-of-interest approach, we assessed group differences in CT at baseline and over time, and tested whether between- and within-subject variations in CT were associated with the frequency of BN symptoms.
resultsReduced CT in the right inferior frontal gyrus persisted over adolescence in BN compared to healthy adolescents, even in those who achieved full or partial remission. Within the BN group, between-subject variations in CT in the inferior and orbital frontal regions were inversely associated with specific BN symptoms, suggesting, on average over time, greater CT reductions in individuals with more frequent BN symptoms.
conclusionReduced CT in inferior frontal regions may contribute to illness persistence into adulthood. Reductions in the thickness of the inferior and orbital frontal regions may be markers of specific BN symptoms. Because our sample size precluded correcting for multiple comparisons, these findings should be replicated in a larger sample. Future study of functional changes in associated fronto-striatal circuits could identify potential circuit-based intervention targets.
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