ArticleEpidemiology and psychiatric sciences2019
Association between schizophrenia and an autoimmune bullous skin disease-pemphigus: a population-based large-scale study.
Article in Epidemiology and psychiatric sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Associations Between Non-neurological Autoimmune Disorders and Psychosis: A Meta-analysis.Biological psychiatry · 2019Pooled it
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Pemphigus Is not Associated with an Increased Risk of Psychiatric Disorders during the Course of the Disease.JID innovations : skin science from molecules to population health · 2026Article
- The role of the microbiota-gut-brain axis in schizophrenia: an immunological perspective.Frontiers in immunology · 2025Review
- The risk of retinal vein occlusion among patients with neovascular age related macular degeneration: a large-scale cohort study.Eye (London, England) · 2023Article
- Burden of pemphigus vulgaris with a particular focus on women: A review.International journal of women's dermatology · 2022Review
- Comorbidities in Patients with Autoimmune Bullous Disorders: Hospital-Based Registry Study.Life (Basel, Switzerland) · 2022Article
- Reduced Serum Levels of Soluble Interleukin-15 Receptor α in Schizophrenia and Its Relationship to the Excited Phenotype.Frontiers in psychiatry · 2022Article
- Epidemiology of Pemphigus.JID innovations : skin science from molecules to population health · 2021Review
- The pathogenesis of bullous skin diseases.Journal of translational autoimmunity · 2019Review
- Pemphigus group: overview, epidemiology, mortality, and comorbidities.Immunologic research · 2018Review
- A rare case report of Lilliputian and Brobdingnagian hallucinations in a case of pemphigus vulgaris.Indian journal of psychiatryArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsImmunological hypotheses have become increasingly prominent suggesting that autoimmunity may be involved in the pathogenesis of schizophrenia. Schizophrenia was found to be associated with a wide range of autoimmune diseases. However, the association between pemphigus and schizophrenia has not been established yet. We aimed to estimate the association between pemphigus and schizophrenia using a large-scale real-life computerised database.
methodsThis study was conducted as a cross-sectional study utilising the database of Clalit Health Services. The proportion of schizophrenia was compared between patients diagnosed with pemphigus and age-, gender- and ethnicity-matched control subjects. Univariate analysis was performed using χ2 and Student's t-test and a multivariate analysis was performed using a logistic regression model.
resultsA total of 1985 pemphigus patients and 9874 controls were included in the study. The prevalence of schizophrenia was greater in patients with pemphigus as compared to the control group (2.0% v. 1.3%, respectively; p = 0.019). In a multivariate analysis, pemphigus was significantly associated with schizophrenia (OR, 1.5; 95% CI, 1.1-2.2). The association was more prominent among females, patients older than 60 years, and Jews.
conclusionsPemphigus is significantly associated with schizophrenia. Physicians treating patients with pemphigus should be aware of this possible association. Patients with pemphigus should be carefully assessed for comorbid schizophrenia and be treated appropriately.
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