Evidence map›Paper›PMID 28942746›Full record

ArticlePalliative & supportive care2018

Rapid autopsy of a patient with recurrent anaplastic ependymoma.

Katharine Rae Lange, Cheryl Fischer, Prajwal Rajappa, Scott Connors, David Pisapia, Jeffrey P Greenfield, Himisha Beltran, Mark Rubin, Juan Miguel Mosquera, Yasmin Khakoo

Abstract readCase Reports
In one paragraph

Article in Palliative & supportive care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Pediatric Oncology Hospice: A Comprehensive Review.The American journal of hospice & palliative care · 2024
    Review
  2. Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2021
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katharine Rae LangeMemorial Sloan Kettering Cancer Center,New York,New York.
Cheryl FischerMemorial Sloan Kettering Cancer Center,New York,New York.
Prajwal RajappaNew York-Presbyterian/Weill Cornell Medical Center,New York,New York.
Scott ConnorsNew York-Presbyterian/Weill Cornell Medical Center,New York,New York.
David PisapiaNew York-Presbyterian/Weill Cornell Medical Center,New York,New York.
Jeffrey P GreenfieldMemorial Sloan Kettering Cancer Center,New York,New York.
Himisha BeltranNew York-Presbyterian/Weill Cornell Medical Center,New York,New York.
Mark RubinNew York-Presbyterian/Weill Cornell Medical Center,New York,New York.
Juan Miguel MosqueraNew York-Presbyterian/Weill Cornell Medical Center,New York,New York.
Yasmin KhakooMemorial Sloan Kettering Cancer Center,New York,New York.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748NIH HHS P30 CA 008748
6 · The paper itself

Abstract

ABSTRACTObjective:Our aim was to outline a procedure for obtaining a rapid autopsy in order to collect high-quality postmortem tissue for genomic analysis.

methodsThis report details a bi-institutional collaborative effort to coordinate a rapid autopsy for a pediatric patient who had died at home. We discuss the scientific rationale for offering a rapid autopsy to caregivers of pediatric patients as well as parental perspectives on broaching the subject of autopsy. We then review the logistics and coordination involved with planning a rapid autopsy and the sequence of events needed to maximize tissue quality.

resultsWe report the successful coordination of a rapid autopsy for a patient who died in a hospice setting at her out-of-state home. The time interval from death to the start of the rapid autopsy procedure was 4.5 hours, despite the logistical considerations demanded by the location of the patient. Tumor aliquots and nonneoplastic tissues were successfully snap frozen for downstream genomic studies. SIGNIFICANCE OF

resultsPhysicians should consider trialing a rapid autopsy program at their institution that could be offered to caregivers of pediatric patients. This case report offers a framework to help clinicians develop their own rapid autopsy programs as well as guidelines to help streamline this process for appropriate candidates going forward.

Indexed as

Time FactorsAutopsyCause of DeathChild, PreschoolDeathEpendymomaFemaleHospice CareHumansMagnetic Resonance ImagingAutopsyCommunicationHospiceNeurooncologyPediatric

Identifiers

PMID28942746
PMCPMC5977387

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.