ArticlePsychological medicine2018
Childhood stress, grown-up brain networks: corticolimbic correlates of threat-related early life stress and adult stress response.
Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01701258 (Early Life Stress and Depression), which is not on this map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Life Stress and Depression: Molecular and Functional Imaging Approaches
Who cites it
56 citing papers in PubMed, 111 citations in OpenAlex.
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- Similarity in Early Life Stress Exposure Is Associated With Similarity in Neural Representations in Early Adulthood.Human brain mapping · 2025Article
- Trauma Timing and Its Impact on Brain Activation During Flexible Emotion Regulation in PTSD: Insights From Functional MRI.Human brain mapping · 2025Article
- The neurobiological effects of childhood maltreatment on brain structure, function, and attachment.European archives of psychiatry and clinical neuroscience · 2025Review
- Inflexible Orbitofrontal Cortex Functional Connectivity From Rest to Acute Stress in Alcohol Use Disorder.Addiction biology · 2025Article
- The effects of adverse life events on brain development in the ABCD study®: a propensity-weighted analysis.Molecular psychiatry · 2025Article
- Associations of interpersonal and socioeconomic early life adversity dimensions with adolescents' corticolimbic circuits, cognition, and mental health.Translational psychiatry · 2025Article
- Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder.Biological psychiatry global open science · 2025Article
- Dissociative experiences alter resting state functional connectivity after childhood abuse.Scientific reports · 2025Article
- Medial prefrontal cortex connectivity with the nucleus accumbens is related to HIV serostatus, perceptions of psychological stress, and monocyte expression of TNF-a.Brain, behavior, & immunity - health · 2024Article
- The Effects of Adverse Life Events on Brain Development in the ABCD StudymedRxiv : the preprint server for health sciences · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.Cell reports · 2024Article
- Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization.Molecular psychiatry · 2024Article
- Cortisol's diurnal rhythm indexes the neurobiological impact of child adversity in adolescence.Biological psychology · 2024Article
- The lateral habenula integrates age and experience to promote social transitions in developing rats.bioRxiv : the preprint server for biology · 2024Article
- Neural response to stress differs by sex in young adulthood.Psychiatry research. Neuroimaging · 2023Article
- Preliminary findings on the effect of childhood trauma on the functional connectivity of the anterior cingulate cortex subregions in major depressive disorder.Frontiers in psychiatry · 2023Article
- A qualitative study of the long-term consequences and adaptation in daily life after replantation surgery at a young age.Hand therapy · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundExposure to threat-related early life stress (ELS) has been related to vulnerability for stress-related disorders in adulthood, putatively via disrupted corticolimbic circuits involved in stress response and regulation. However, previous research on ELS has not examined both the intrinsic strength and flexibility of corticolimbic circuits, which may be particularly important for adaptive stress responding, or associations between these dimensions of corticolimbic dysfunction and acute stress response in adulthood.
methodsSeventy unmedicated women varying in history of threat-related ELS completed a functional magnetic resonance imaging scan to evaluate voxelwise static (overall) and dynamic (variability over a series of sliding windows) resting-state functional connectivity (RSFC) of bilateral amygdala. In a separate session and subset of participants (n = 42), measures of salivary cortisol and affect were collected during a social-evaluative stress challenge.
resultsHigher severity of threat-related ELS was related to more strongly negative static RSFC between amygdala and left dorsolateral prefrontal cortex (DLPFC), and elevated dynamic RSFC between amygdala and rostral anterior cingulate cortex (rACC). Static amygdala-DLPFC antagonism mediated the relationship between higher severity of threat-related ELS and blunted cortisol response to stress, but increased dynamic amygdala-rACC connectivity weakened this mediated effect and was related to more positive post-stress mood.
conclusionsThreat-related ELS was associated with RSFC within lateral corticolimbic circuits, which in turn was related to blunted physiological response to acute stress. Notably, increased flexibility between the amygdala and rACC compensated for this static disruption, suggesting that more dynamic medial corticolimbic circuits might be key to restoring healthy stress response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.