ArticleBrain connectivity2017
Integration and Segregation of Default Mode Network Resting-State Functional Connectivity in Transition-Age Males with High-Functioning Autism Spectrum Disorder: A Proof-of-Concept Study.
Article in Brain connectivity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Resting-state abnormalities in functional connectivity of the default mode network in autism spectrum disorder: a meta-analysis.Brain imaging and behavior · 2021Pooled it
- Functional Connectivity of the Neonatal Cerebellum is Impacted by Sex and Polygenic Liability for Autism.medRxiv : the preprint server for health sciences · 2026Article
- Alterations in self-related brain networks in autism spectrum disorder: a systematic review of functional and structural magnetic resonance imaging studies.Psychoradiology · 2026Review
- Brain Activity Within Prefrontal Cortex: A Resting-State fNIRS Comparative Study in High-Functioning Autism Preschoolers and Typically Developed Peers.Journal of biophotonics · 2025Article
- Language networks in Autism Spectrum Disorder: A systematic review of connectivity-based fMRI studies.Review journal of autism and developmental disorders · 2025Article
- High-precision machine learning identifies a reproducible functional connectivity signature of autism spectrum diagnosis in a subset of individuals.GigaScience · 2025Article
- Co-activation pattern alterations in autism spectrum disorder-A volume-wise hierarchical clustering fMRI study.Brain and behavior · 2021Article
- Developmental pattern of the cortical topology in high-functioning individuals with autism spectrum disorder.Human brain mapping · 2021Article
- Improving Between-Group Effect Size for Multi-Site Functional Connectivity Data via Site-Wise De-Meaning.Frontiers in computational neuroscience · 2021Article
- Genetics of structural and functional brain changes in autism spectrum disorder.Translational psychiatry · 2020Review
- Functional Connectivity of the Striatum as a Neural Correlate of Symptom Severity in Patient with Obsessive-Compulsive Disorder.Psychiatry investigation · 2020Article
- Altered resting-state functional connectivity in young children at familial high risk for psychotic illness: A preliminary study.Schizophrenia research · 2020Article
- A Review of Default Mode Network Connectivity and Its Association With Social Cognition in Adolescents With Autism Spectrum Disorder and Early-Onset Psychosis.Frontiers in psychiatry · 2020Review
- MRI Insights Into Adolescent Neurocircuitry-A Vision for the Future.Frontiers in human neuroscience · 2020Article
- Intrinsic Functional Connectivity of Dentate Nuclei in Autism Spectrum Disorder.Brain connectivity · 2019Article
- The Superficial White Matter in Autism and Its Role in Connectivity Anomalies and Symptom Severity.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Atypical functional connectome hierarchy in autism.Nature communications · 2019Article
- Distinct Patterns of Atypical Functional Connectivity in Lower-Functioning Autism.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2019Article
- Interrupted Time Experience in Autism Spectrum Disorder: Empirical Evidence from Content Analysis.Journal of autism and developmental disorders · 2019Article
- Intertemporal decision-making-related brain states predict adolescent drug abuse intervention responses.NeuroImage. Clinical · 2019Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
The aim of this study is to assess the resting-state functional connectivity (RsFc) profile of the default mode network (DMN) in transition-age males with autism spectrum disorder (ASD). Resting-state blood oxygen level-dependent functional magnetic resonance imaging data were acquired from adolescent and young adult males with high-functioning ASD (n = 15) and from age-, sex-, and intelligence quotient-matched healthy controls (HCs; n = 16). The DMN was examined by assessing the positive and negative RsFc correlations of an average of the literature-based conceptualized major DMN nodes (medial prefrontal cortex [mPFC], posterior cingulate cortex, bilateral angular, and inferior temporal gyrus regions). RsFc data analysis was performed using a seed-driven approach. ASD was characterized by an altered pattern of RsFc in the DMN. The ASD group exhibited a weaker pattern of intra- and extra-DMN-positive and -negative RsFc correlations, respectively. In ASD, the strength of intra-DMN coupling was significantly reduced with the mPFC and the bilateral angular gyrus regions. In addition, the polarity of the extra-DMN correlation with the right hemispheric task-positive regions of fusiform gyrus and supramarginal gyrus was reversed from typically negative to positive in the ASD group. A wide variability was observed in the presentation of the RsFc profile of the DMN in both HC and ASD groups that revealed a distinct pattern of subgrouping using pattern recognition analyses. These findings imply that the functional architecture profile of the DMN is altered in ASD with weaker than expected integration and segregation of DMN RsFc. Future studies with larger sample sizes are warranted.
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Registered trials
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