Evidence map›Paper›PMID 28942574›Full record

ReviewCurrent infectious disease reports2017

Once-Daily Treatments for Methicillin-Susceptible Staphylococcus aureus Bacteremia: Are They Good Enough?

Sylvain A Lother, Natasha Press

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current infectious disease reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04141787 (Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04141787 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

Ceftriaxone as Home Intravenous Therapy for Deep-Seated Staphylococcal Infections, a Randomized Non-Inferiority Trial

TypeinterventionalSponsorVancouver Island Health AuthorityRan2019 to 2024Enrolled310ConditionsStaphylococcal Infections, Osteomyelitis, CNS Infection, Septic ArthritisArmsCeftriaxone, Usual Antibiotics (Cloxacillin, Cefazolin, Daptomycin)
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Synergistic Antimicrobial Activity of Ceftriaxone andAntibiotics (Basel, Switzerland) · 2023
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sylvain A LotherDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, 452D, Heather Pavilion East, VGH, 2733 Heather Street, Vancouver, BC, V5Z 3J5, Canada. sa.lother@me.com.
Natasha PressDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine, University of British Columbia, 452D, Heather Pavilion East, VGH, 2733 Heather Street, Vancouver, BC, V5Z 3J5, Canada.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of the reviewMethicillin-sensitive Staphylococcus aureus (MSSA) bacteremia is a common cause of morbidity and mortality. First-line treatment requires frequent daily doses of an anti-staphylococcal beta-lactam. However, some physicians prescribe simpler once-daily regimens to improve compliance and improve healthcare utilization. We reviewed the literature regarding advantages, pitfalls, and efficacy of once-daily treatment options for MSSA bacteremia. RECENT

findingsSeveral once-daily antibiotics are effective in vitro against MSSA (ceftriaxone, daptomycin, telavancin, dalbavancin, oritavancin, tedizolid, ertapenem, fluoroquinolones, and others), but there is insufficient evidence to support these agents for MSSA bacteremia. Ceftriaxone may be considered for therapy completion with MSSA bacteremia from osteomyelitis, and daptomycin may be considered in patients who cannot tolerate first-line therapy. However, they have not been compared to traditional second-line agents, and their role remains uncertain. Current evidence does not support the use of once-daily treatment options for MSSA bacteremia.

Indexed as

BacteremiaMethicillin-sensitive Staphylococcus aureusOnce-dailyTreatment

Identifiers

PMID28942574
OpenAlexW2758910124

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.