ArticleCirculation2017
Binding of FUN14 Domain Containing 1 With Inositol 1,4,5-Trisphosphate Receptor in Mitochondria-Associated Endoplasmic Reticulum Membranes Maintains Mitochondrial Dynamics and Function in Hearts in Vivo.
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Article in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 2 of them syntheses that pooled it.
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Who cites it
198 citing papers in PubMed, 2 syntheses or guidelines pooled it, 307 citations in OpenAlex.
- Reprogramming heart failure: physiological orchestration and mechanistic decoding of exercise benefits.BMC cardiovascular disorders · 2025Pooled it
- MAM kinases: physiological roles, related diseases, and therapeutic perspectives-a systematic review.Cellular & molecular biology letters · 2025Pooled it
- Mitochondria‑associated endoplasmic reticulum membranes in degenerative musculoskeletal disorders: Mechanistic evidence and therapeutic perspectives (Review).Molecular medicine reports · 2026Review
- Mitophagy coordinates organelle crosstalk in health and diseases.Signal transduction and targeted therapy · 2026Review
- Mitochondria-endoplasmic reticulum-lipid droplet crosstalk in lipid metabolic reprogramming in type 2 diabetes mellitus.Journal of lipid research · 2026Review
- Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review).International journal of molecular medicine · 2026Review
- Intermembrane coupling between Bcl-xL and the IPCell reports · 2026Article
- Molecular diversity of mitochondrial autophagy receptors: context-dependent effects in human health and disease.Cell death discovery · 2026Review
- Huoxue Qianyang Qutan Recipe limits cardiac remodeling by regulating FUNDC1/IP3R2 signaling pathway in obese hypertensive rats.Scientific reports · 2026Article
- Beyond the Powerhouse: Mitochondrial Crosstalk as a Master Regulator of Cardiac Metabolic Homeostasis and Failure.Journal of cardiovascular translational research · 2026Review
- Mitochondria-ER contact sites (MERCS) in the cell cycle: molecular architecture and functional remodeling across cellular states.BMC biology · 2026Review
- Organelle contact sites in cancer cells.Cell death & disease · 2026Review
- Mitochondrial interplay with membrane organelles in health and disease.Cell communication and signaling : CCS · 2026Review
- Endoplasmic Reticulum-Mitochondrial Crosstalk in Calcium Regulation: Mechanistic Insights and Therapeutic Implications in Traumatic Brain Injury.Molecular neurobiology · 2026Review
- The PVAT-MAMs Axis in Atherosclerosis: A Hypothesis-Driven Cross-Scale Conceptual Framework.International journal of molecular sciences · 2026Review
- The spatiotemporal dynamics of MAMs: mechanisms, pathologies, and therapeutic rewiring.Cellular & molecular biology letters · 2026Review
- Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review).International journal of molecular medicine · 2026Review
- Endothelial FUNDC1 regulates metabolic reprogramming and the obesity-diabetes transition through the SIRT3/GATA2/endothelin-1 axis.Nature communications · 2026Article
- Mitochondria-endoplasmic reticulum contact sites in hepatocytic senescence.Cellular & molecular biology letters · 2026Review
- The Pathophysiological Role of Mitochondria-associated Membranes in Coronary Artery Disease and Atherosclerosis.Current medicinal chemistry · 2026Review
138 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 2 institutions in 1 country.
Shengnan WuCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.).
Qiulun LuCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.).
Qilong WangCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.).
Ye DingCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.).
Zejun MaCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.).
Xiaoxiang MaoCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.).
Kai HuangCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.).
Zhonglin XieCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.). mzou@gsu.edu zxie@gsu.edu.
Ming-Hui ZouCenter for Molecular and Translational Medicine, Georgia State University, Atlanta (S.W., Q.L., Q.W., Y.D., Z.M., Z.X., M.-H.Z.). Wuhan Union Hospital, Huazhong University of Science and Technology, Hubei, China (X.M., K.H.). mzou@gsu.edu zxie@gsu.edu.
Union Hospital · CNUnion Hospital · CN
Funding
Reactive Nitrogen species and Diabetic Endothelial DysfunctionR01HL079584 · NHLBI · UNIVERSITY OF TENNESSEE KNOXVILLE · PI ZOU, MING-HUI · 2004 to 2021
$7.3MInflammasome and unstable atherosclerotic plaquesR01HL089920 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2008 to 2022
$6.9MAMP-Activated Protein Kinase in DiabetesR01HL080499 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2006 to 2019
$5.8MControlling VSMC Proliferation and MigrationR01HL110488 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2011 to 2020
$3.9MOxidant stress and diabetic endothelial dysfunctionR01HL074399 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2005 to 2013
$3.2MSNRK in ischemic vascular diseasesR01HL142287 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2018 to 2022
$3.0MFUNDC1 and diabetic cardiomyopathyR01HL137371 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2017 to 2020
$2.8MAutophagy and VSMC migrationR01HL132500 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2016 to 2019
$2.7MSuppression of Autophagy-Dependent Clearance Mitochondria in Type 2 DiabetesR01HL128014 · NHLBI · GEORGIA STATE UNIVERSITY · PI XIE, ZHONGLIN, ZOU, MING-HUI · 2015 to 2018
$2.4MLiver kinase B1 in angiogenesisR01CA213022 · NCI · GEORGIA STATE UNIVERSITY · PI ZOU, MING-HUI · 2017 to 2021
$2.3MSirt1, Vascular Aging, and Aortic AneurysmR01AG047776 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ZOU, MING-HUI · 2014 to 2018
$1.5MNCI NIH HHS R01 CA213022NHLBI NIH HHS R01 HL074399NHLBI NIH HHS R01 HL079584NHLBI NIH HHS R01 HL080499NHLBI NIH HHS R01 HL089920NHLBI NIH HHS R01 HL110488NHLBI NIH HHS R01 HL128014NHLBI NIH HHS R01 HL132500NHLBI NIH HHS R01 HL137371NHLBI NIH HHS R01 HL142287NIA NIH HHS R01 AG047776
Abstract
backgroundFUN14 domain containing 1 (FUNDC1) is a highly conserved outer mitochondrial membrane protein. The aim of this study is to examine whether FUNDC1 modulates the mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs), mitochondrial morphology, and function in cardiomyocytes and intact hearts.
methodsThe impacts of FUNDC1 on MAMs formation and cardiac functions were studied in mouse neonatal cardiomyocytes, in mice with cardiomyocyte-specific
resultsIn mouse neonatal cardiomyocytes and intact hearts, FUNDC1 was localized in MAMs by binding to ER-resided inositol 1,4,5-trisphosphate type 2 receptor (IP
conclusionsWe conclude that FUNDC1 binds to IP
Indexed as
Mitochondrial DynamicsAnimalsBinding SitesCalciumCase-Control StudiesCells, CulturedCyclic AMP Response Element-Binding ProteinEndoplasmic ReticulumGenetic Predisposition to DiseaseHeart FailureHumansInositol 1,4,5-Trisphosphate ReceptorsIntracellular MembranesMembrane ProteinsMice, KnockoutMitochondria, HeartCalciumCREB1 protein, humanCreb1 protein, mouseCyclic AMP Response Element-Binding ProteinFIS1 protein, humanFIS1 protein, mouseFUNDC1 protein, humanFUNDC1 protein, mouseInositol 1,4,5-Trisphosphate ReceptorsIp3r2 protein, mouseITPR2 protein, humanMembrane ProteinsMitochondrial ProteinscardiomyopathyFUNDC1heart failureIP3R2MAMs
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.