Evidence map›Paper›PMID 28942148›Full record

ArticleBiochemical and biophysical research communications2017

High glucose derived endothelial microparticles increase active caspase-3 and reduce microRNA-Let-7a expression in endothelial cells.

Tyler D Bammert, Jamie G Hijmans, Whitney R Reiakvam, Ma'ayan V Levy, Lillian M Brewster, Zoe A Goldthwaite, Jared J Greiner, Kelly A Stockelman, Christopher A DeSouza

Abstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Endothelin-1-induced endothelial microvesicles impair endothelial cell function.Journal of applied physiology (Bethesda, Md. : 1985) · 2020
    Article
  10. Article
  11. Review
  12. Review
  13. Effects of HIV-1 gp120 and TAT-derived microvesicles on endothelial cell function.Journal of applied physiology (Bethesda, Md. : 1985) · 2019
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tyler D BammertIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Jamie G HijmansIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Whitney R ReiakvamIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Ma'ayan V LevyIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Lillian M BrewsterIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Zoe A GoldthwaiteIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Jared J GreinerIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Kelly A StockelmanIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
Christopher A DeSouzaIntegrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA. Electronic address: desouzac@colorado.edu.

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
HIV-1, Insufficient Sleep and Vascular Endothelial DysfunctionR01HL131458 · NHLBI · UNIVERSITY OF COLORADO · PI CONNICK, ELIZABETH, DESOUZA, CHRISTOPHER A · 2016 to 2019
$3.0M
Sleep and Blood Pressure-Related Endothelial AbnormalitiesR01HL135598 · NHLBI · UNIVERSITY OF COLORADO · PI DESOUZA, CHRISTOPHER A, STAUFFER, BRIAN L · 2017 to 2020
$3.0M
NHLBI NIH HHS R01 HL131458NHLBI NIH HHS R01 HL135598NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

The experimental aim of this study was to determine the effects of high glucose-induced endothelial microparticles (EMPs) on endothelial cell susceptibility to apoptosis. Human umbilical vein endothelial cells (HUVECs) were cultured (3rd passage) and plated in 6-well plates at a density of 5.0 × 10

Indexed as

ApoptosisCaspase 3Cell-Derived MicroparticlesDown-RegulationEndothelial CellsEnzyme ActivationGlucoseHumansHuman Umbilical Vein Endothelial CellsHyperglycemiaMicroRNAsCaspase 3GlucoseMicroRNAsmirnlet7 microRNA, humanApoptosisCaspase-3Endothelial cellsGlucoseMicroRNAmiR-Let-7a

Identifiers

PMID28942148
PMCPMC5652070

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.