ArticleNeuroImage2017
Volumetric grey matter alterations in adolescents and adults born very preterm suggest accelerated brain maturation.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 87 citations in OpenAlex.
- Morphometric alterations of the gray matter of the frontal lobe during childhood in healthy children born prematurely. Repercussions of foetal and postnatal growth restriction.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Perinatal Factors and Neuroimaging Changes for Brain Maturation Among Adolescents.JAMA network open · 2026Article
- Neuroanatomical subtypes of preterm adolescents.Molecular psychiatry · 2026Article
- Long-Term Consequences of Preterm Birth: A Lifespan Perspective.Developmental neuroscience · 2026Review
- Relationships between cerebral blood flow and cognition in young adults born very preterm and at term.Scientific reports · 2026Article
- Long-term effects of preterm birth on cortical folding trajectories in early childhood.Brain communications · 2026Article
- Variation in moment-to-moment brain state engagement follows a consistent trajectory during development.Neuron · 2025Article
- Emergence of a synergistic scaffold in the brains of human infants.Communications biology · 2025Article
- Prematurity is associated with white matter T2 MRI visible perivascular spaces in very preterm-born neonates.Brain communications · 2025Article
- Retinal biomarkers in schizophrenia spectrum disorders: evidence and implications for the neurodevelopmental and neurodegenerative models.Frontiers in medicine · 2025Review
- Exploring functional connectivity in clinical and data-driven groups of preterm and term adults.Brain communications · 2025Article
- Motor predictors of cortical brain development and full-IQ in children born extremely preterm with and without discrete white matter abnormalities.Brain structure & function · 2024Article
- Variation in moment-to-moment brain state engagement changes across development and contributes to individual differences in executive function.bioRxiv : the preprint server for biology · 2024Article
- Association of birthweight and risk of incident dementia: a prospective cohort study.GeroScience · 2024Article
- Corpus callosum long-term biometry in very preterm children related to cognitive and motor outcomes.Pediatric research · 2024Article
- Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions.Developmental cognitive neuroscience · 2024Article
- Indirect evidence for altered dopaminergic neurotransmission in very premature-born adults.Human brain mapping · 2023Article
- MRI-based brain age prediction model for children under 3 years old using deep residual network.Brain structure & function · 2023Article
- A stable and replicable neural signature of lifespan adversity in the adult brain.Nature neuroscience · 2023Article
- Maturational networks of human fetal brain activity reveal emerging connectivity patterns prior to ex-utero exposure.Communications biology · 2023Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Previous research investigating structural neurodevelopmental alterations in individuals who were born very preterm demonstrated a complex pattern of grey matter changes that defy straightforward summary. Here we addressed this problem by characterising volumetric brain alterations in individuals who were born very preterm from adolescence to adulthood at three hierarchically related levels - global, modular and regional. We demarcated structural components that were either particularly resilient or vulnerable to the impact of very preterm birth. We showed that individuals who were born very preterm had smaller global grey matter volume compared to controls, with subcortical and medial temporal regions being particularly affected. Conversely, frontal and lateral parieto-temporal cortices were relatively resilient to the effects of very preterm birth, possibly indicating compensatory mechanisms. Exploratory analyses supported this hypothesis by showing a stronger association between lateral parieto-temporal volume and IQ in the very preterm group compared to controls. We then related these alterations to brain maturation processes. Very preterm individuals exhibited a higher maturation index compared to controls, indicating accelerated brain maturation and this was specifically associated with younger gestational age. We discuss how the findings of accelerated maturation might be reconciled with evidence of delayed maturation at earlier stages of development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.