Evidence map›Paper›PMID 28941984›Full record

ArticleDevelopmental biology2017

Neural crest cells utilize primary cilia to regulate ventral forebrain morphogenesis via Hedgehog-dependent regulation of oriented cell division.

Elizabeth N Schock, Samantha A Brugmann

Open access · greenAbstract read
In one paragraph

Article in Developmental biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Disruption of DNA methylation-mediated cranial neural crest proliferation and differentiation causes orofacial clefts in mice.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Zebrafish crocc2 mutants exhibit divergent craniofacial shape, misregulated variability, and aberrant cartilage morphogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth N SchockDivision of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Samantha A BrugmannDivision of Plastic Surgery, Department of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Division of Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. Electronic address: samantha.brugmann@cchmc.org.
Cincinnati Children's Hospital Medical Center · US

Funding

The Role of Primary Cilia in Murine Craniofacial DevelopmentR01DE023804 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI BRUGMANN, SAMANTHA A · 2014 to 2017
$1.6M
The role of ectodermal primary cilia in murine orofacial developmentF31DE025537 · NIDCR · CINCINNATI CHILDRENS HOSP MED CTR · PI SCHOCK, ELIZABETH (BETSY) · 2015 to 2017
$89k
NIDCR NIH HHS F31 DE025537NIDCR NIH HHS R01 DE023804
6 · The paper itself

Abstract

Development of the brain directly influences the development of the face via both physical growth and Sonic hedgehog (SHH) activity; however, little is known about how neural crest cells (NCCs), the mesenchymal population that comprise the developing facial prominences, influence the development of the brain. We utilized the conditional ciliary mutant Wnt1-Cre;Kif3a

Indexed as

Cell DivisionMorphogenesisAnimalsBody PatterningCell PolarityCiliaFaceGene Expression Regulation, DevelopmentalHedgehog ProteinsIntegrasesKinesinsMiceModels, BiologicalMutationNeural CrestNeural PlateCre recombinaseHedgehog ProteinsIntegrasesKif3a protein, mouseKinesinsShh protein, mouseSOXE Transcription FactorsWnt ProteinsHedgehog signalingneural crestprimary ciliaSox10-Creventral forebrainWnt1-Cre

Identifiers

PMID28941984
PMCPMC5658255
OpenAlexW2756988395

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.