Evidence map›Paper›PMID 28941962›Full record

ReviewSeminars in perinatology2017

Racial and ethnic differences in preterm birth: A complex, multifactorial problem.

Tracy A Manuck

2 registry-linked trialsAbstract readComparative StudyReview
In one paragraph

Review in Seminars in perinatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 166 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 5 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06281262 unknown statusnot on this mapstarted 2023, after this paper: background citation

The Role of Selected Immunological Indicators and Microbiota in Patients Experiencing Premature Birth and Preeclampsia

TypeobservationalSponsorGeneral University Hospital, PragueRan2023 to 2025Enrolled100ConditionsPreterm Birth, PreeclampsiaArmsPeripheral blood collection, Swab sample collection
NCT07216898 terminatednot on this mapstarted 2025, after this paper: background citation

You Have the Right to Know: Empowering Women Through Clean Beauty Research and Education

TypeobservationalSponsorRutgers, The State University of New JerseyRan2025 to 2026Enrolled38ConditionsHealth Disparities, EducationArmsChemical Exposure Prevention
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 5 syntheses or guidelines pooled it, 325 citations in OpenAlex.

  1. Pooled it
  2. COVID-19 vaccine and pregnancy outcomes: A systematic review and meta-analysis.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2022
    Pooled it
  3. Pooled it
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  6. Exploring Social and Demographic Factors as Determinants of Intestinal Inflammation in Very Low Birth-Weight Infants.Advances in neonatal care : official journal of the National Association of Neonatal Nurses · 2021
    Trial
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Voting Restrictions and Increased Odds of Adverse Birth Outcomes in the US.Journal of racial and ethnic health disparities · 2026
    Article
  12. Review
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  15. Maternal and neonatal outcomes with different screening strategies for gestational diabetes mellitus: a retrospective cohort study.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2025
    Article
  16. Article
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  19. Article
  20. Article

106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Tracy A ManuckDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, 3010 Old Clinic Building, CB#7516, Chapel Hill, NC 27599-7516. Electronic address: tmanuck@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

The Pharmacoepigenomics of Recurrent Preterm Birth in Non-Hispanic Black WomenR01MD011609 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MANUCK, TRACY A. · 2017 to 2021
$3.8M
NIMHD NIH HHS R01 MD011609
6 · The paper itself

Abstract

Preterm birth remains the leading cause of morbidity and mortality among nonanomalous neonates, and is a major public health problem. Non-Hispanic black women have a 2-fold greater risk for preterm birth compared with non-Hispanic white race. The reasons for this disparity are poorly understood and cannot be explained solely by sociodemographic factors. Underlying factors including a complex interaction between maternal, paternal, and fetal genetics, epigenetics, the microbiome, and these sociodemographic risk factors likely underlies the differences between racial groups, but these relationships are currently poorly understood. This article reviews the epidemiology of disparities in preterm birth rates and adverse pregnancy outcomes and discuss possible explanations for the racial and ethnic differences, while examining potential solutions to this major public health problem.

Indexed as

Public HealthBlack or African AmericanCross-Cultural ComparisonFemaleGenetic Predisposition to DiseaseHealthcare DisparitiesHumansInfant, NewbornPregnancyPregnancy OutcomePremature BirthPrenatal CareRacial GroupsSocioeconomic FactorsUnited StatesWhite PeopleNeonatal outcomesPerinatal epidemiologyPreterm birthRacial disparity

Identifiers

PMID28941962
PMCPMC6381592
OpenAlexW2759161062

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.