Evidence map›Paper›PMID 28941930›Full record

ArticleJournal of pediatric surgery2017

Cannulating the contraindicated: effect of low birth weight on mortality in neonates with congenital diaphragmatic hernia on extracorporeal membrane oxygenation.

Patrick T Delaplain, Lishi Zhang, Yanjun Chen, Danh V Nguyen, Matteo Di Nardo, John Patrick Cleary, Peter T Yu, Yigit S Guner

Open access · greenAbstract read
In one paragraph

Article in Journal of pediatric surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. Hemodynamic precision to guide surgical timing for neonates with congenital diaphragmatic hernia: a narrative review.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Patrick T DelaplainUniversity of California, Irvine Medical Center, Department of Surgery, Orange, CA.
Lishi ZhangUniversity of California Irvine, Biostatistics, Institute for Clinical and Translational Science, Irvine, CA.
Yanjun ChenUniversity of California Irvine, Biostatistics, Institute for Clinical and Translational Science, Irvine, CA.
Danh V NguyenUniversity of California, Irvine School of Medicine, Department of Medicine, Orange, CA.
Matteo Di NardoPediatric Intensive Care Unit, Children's Hospital Bambino Gesù, IRCCS, Rome, Italy.
John Patrick ClearyChildren's Hospital of Orange County, Division of Neonatology, Orange, CA.
Peter T YuUniversity of California, Irvine Medical Center, Department of Surgery, Orange, CA; Children's Hospital of Orange County, Division of Pediatric Surgery, Orange, CA.
Yigit S GunerUniversity of California, Irvine Medical Center, Department of Surgery, Orange, CA; Children's Hospital of Orange County, Division of Pediatric Surgery, Orange, CA. Electronic address: yguner@uci.edu.
University of California, Irvine · USChildren's Hospital of Orange County · USUniversity of California, Irvine Medical Center · USBambino Gesù Children's Hospital · IT

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
NCATS NIH HHS UL1 TR001414
6 · The paper itself

Abstract

background/purposeRestrictions for ECMO in neonates include birth weight less than 2kg (BW <2kg) and/or gestational age less than 34weeks (GA <34weeks). We sought to describe their relationship on mortality.

methodsNeonates with a primary diagnosis code of CDH were identified in the Extracorporeal Life Support Organization (ELSO) registry, and logistic regression models were used to examine the effect of BW <2kg and GA <34weeks on mortality.

resultsWe identified 7564 neonates with CDH. The overall mortality was 50%. There was a significantly higher risk of death with unadjusted odds ratio (OR) 2.39 (95% confidence interval [CI]: 1.53-3.74; P<0.01) for BW <2kg neonates. The adjusted OR of death for BW <2kg neonates remained significantly high with over two-fold increase in the odds of mortality when adjusted for potential confounding variables (OR 2.11, 95% CI: 1.30-3.43; P<0.01). However, no difference in mortality was observed in neonates with GA <34weeks.

conclusionsWhile mortality among CDH neonates with a BW <2kg was substantially increased, GA <34weeks was not significantly associated with mortality. Effort should be made to identify the best candidates for ECMO in this high-risk group and develop treatment strategies to optimize their survival. TYPE OF STUDY: Case-Control Study, Retrospective Comparative Study. LEVEL OF EVIDENCE: Level III.

Indexed as

Birth WeightInfant, Low Birth WeightExtracorporeal Membrane OxygenationFemaleGestational AgeHernias, Diaphragmatic, CongenitalHumansInfant, NewbornLogistic ModelsMaleOdds RatioPrognosisRegistriesRetrospective StudiesCDHECMOLow birthweightLow gestation

Identifiers

PMID28941930
PMCPMC5723552
OpenAlexW2753541323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.