Evidence map›Paper›PMID 28941531›Full record

ReviewSeminars in pediatric neurology2017

Disentangling How the Brain is "Wired" in Cortical (Cerebral) Visual Impairment.

Lotfi B Merabet, D Luisa Mayer, Corinna M Bauer, Darick Wright, Barry S Kran

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in pediatric neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 61 citations in OpenAlex.

  1. Trial
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  6. Cerebral visual impairment (CVI) overlooked: A retrospective review of missed opportunities to diagnose CVI.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025
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  7. Review
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  14. Development of BOLD Response to Motion in Human Infants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  15. Review
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  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Lotfi B MerabetFrom the *Department of Ophthalmology, Laboratory for Visual Neuroplasticity, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. Electronic address: lotfi_merabet@meei.harvard.edu.
D Luisa Mayer†Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, MA; ‡New England College of Optometry, Boston, MA; §NECO Clinical Network, Perkins School for the Blind, Watertown, MA.
Corinna M BauerFrom the *Department of Ophthalmology, Laboratory for Visual Neuroplasticity, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA.
Darick Wright¶Vision Studies Program, School for Global Inclusion and Social Development, University of Massachusetts, Boston, MA.
Barry S Kran‡New England College of Optometry, Boston, MA; §NECO Clinical Network, Perkins School for the Blind, Watertown, MA.
Perkins School for Blind · USHarvard University · USMassachusetts Eye and Ear Infirmary · USUniversity of Massachusetts Boston · US

Funding

Audio-Haptic Virtual Environments for Large-Scale Navigation in the BlindR01EY019924 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI MERABET, LOTFI · 2010 to 2018
$3.5M
NEI NIH HHS R01 EY019924
6 · The paper itself

Abstract

Cortical (cerebral) visual impairment (CVI) results from perinatal injury to visual processing structures and pathways of the brain and is the most common cause of severe visual impairment or blindness in children in developed countries. Children with CVI display a wide range of visual deficits including decreased visual acuity, impaired visual field function, as well as impairments in higher-order visual processing and attention. Together, these visual impairments can dramatically influence a child's development and well-being. Given the complex neurologic underpinnings of this condition, CVI is often undiagnosed by eye care practitioners. Furthermore, the neurophysiological basis of CVI in relation to observed visual processing deficits remains poorly understood. Here, we present some of the challenges associated with the clinical assessment and management of individuals with CVI. We discuss how advances in brain imaging are likely to help uncover the underlying neurophysiology of this condition. In particular, we demonstrate how structural and functional neuroimaging approaches can help gain insight into abnormalities of white matter connectivity and cortical activation patterns, respectively. Establishing a connection between how changes within the brain relate to visual impairments in CVI will be important for developing effective rehabilitative and education strategies for individuals living with this condition.

Indexed as

BrainHumansNeural PathwaysVision Disorders

Identifiers

PMID28941531
PMCPMC5659284
OpenAlexW2607325097

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.