Evidence map›Paper›PMID 28941396›Full record

ArticleUltrasonics2018

Real-time ultrasound angiography using superharmonic dual-frequency (2.25MHz/30MHz) cylindrical array: In vitro study.

Zhuochen Wang, K Heath Martin, Paul A Dayton, Xiaoning Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasonics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhuochen WangDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA; State Key Laboratory of Precision Measuring Technology & Instruments, Tianjin University, Tianjin 300072, PR China.
K Heath MartinJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC 27599, USA.
Paul A DaytonJoint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, NC 27599, USA.
Xiaoning JiangDepartment of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA. Electronic address: xjiang5@ncsu.edu.

Funding

Dual-frequency intravascular arrays for functional imaging of atherosclerosisR01EB015508 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI JIANG, XIAONING · 2012 to 2015
$2.0M
NIBIB NIH HHS R01 EB015508
6 · The paper itself

Abstract

Recent studies suggest that dual-frequency intravascular ultrasound (IVUS) transducers allow detection of superharmonic bubble signatures, enabling acoustic angiography for microvascular and molecular imaging. In this paper, a dual-frequency IVUS cylindrical array transducer was developed for real-time superharmonic imaging. A reduced form-factor lateral mode transmitter (2.25MHz) was used to excite microbubbles effectively at 782kPa with single-cycle excitation while still maintaining the small size and low profile (5Fr) (3Fr=1mm) for intravascular imaging applications. Superharmonic microbubble responses generated in simulated microvessels were captured by the high frequency receiver (30MHz). The axial and lateral full-width half-maximum of microbubbles in a 200-μm-diameter cellulose tube were measured to be 162μm and 1039μm, respectively, with a contrast-to-noise ratio (CNR) of 16.6dB. Compared to our previously reported single-element IVUS transducers, this IVUS array design achieves a higher CNR (16.6dBvs 11dB) and improved axial resolution (162μmvs 616μm). The results show that this dual-frequency IVUS array transducer with a lateral-mode transmitter can fulfill the native design requirement (∼3-5Fr) for acoustic angiography by generating nonlinear microbubble responses as well as detecting their superharmonic responses in a 5Fr form factor.

Indexed as

AngiographyEquipment DesignIn Vitro TechniquesMicrobubblesMicrovesselsPhantoms, ImagingTransducersUltrasonographyAcoustic angiographyDual-frequency ultrasoundIVUS arrayLateral mode transducerSuperharmonic

Identifiers

PMID28941396
PMCPMC5659895

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.