Evidence map›Paper›PMID 28941322›Full record

ArticleStem cells translational medicine2017

Stromal Cell-Derived Factor-1 Mediates Cardiac Allograft Tolerance Induced by Human Endometrial Regenerative Cell-Based Therapy.

Xu Lan, Grace Wang, Xiaoxi Xu, Shanzheng Lu, Xiang Li, Baoren Zhang, Ganggang Shi, Yiming Zhao, Caigan Du, Hao Wang

Open access · goldAbstract read
In one paragraph

Article in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. The Role of Macrophages in Oocyte Donation Pregnancy: A Systematic Review.International journal of molecular sciences · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Xu LanDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.ORCID 0000-0003-0838-6473
Grace WangFaculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Xiaoxi XuDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Shanzheng LuDepartment of Anorectal Surgery, People's Hospital of Hunan Province, First Affiliated Hospital of Hunan Normal University, Changsha, Hunan Province, People's Republic of China.
Xiang LiDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Baoren ZhangDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Ganggang ShiDepartment of Colorectal Surgery, The Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China.
Yiming ZhaoDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Caigan DuDepartment of Urologic Sciences, the University of British Columbia, Vancouver, British Columbia, Canada.
Hao WangDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Tianjin Medical University General Hospital · CNHunan Normal University · CNSecond Hospital of Tianjin Medical University · CNUniversity of British Columbia · CAUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial regenerative cells (ERCs) are mesenchymal-like stromal cells, and their therapeutic potential has been tested in the prevention of renal ischemic reperfusion injury, acute liver injury, ulcerative colitis, and immunosuppression. However, their potential in the induction of transplant tolerance has not been investigated. The present study was undertaken to investigate the efficacy of ERCs in inducing cardiac allograft tolerance and the function of stromal cell-derived factor-1 (SDF-1) in the ERC-mediated immunoregulation. The inhibitory efficacy of human ERCs in the presence or absence of rapamycin was examined in both mouse cardiac allograft models between BALB/c (H-2

Indexed as

Transplantation ToleranceAdult Stem CellsAnimalsCells, CulturedChemokine CXCL12EndometriumFemaleGraft RejectionHeart TransplantationHumansMaleMiceMice, Inbred BALB CMice, Inbred C57BLStem Cell TransplantationChemokine CXCL12Allograft toleranceCardiac transplantationHuman endometrial regenerative cellsMiceStromal cell-derived factor-1

Identifiers

PMID28941322
PMCPMC6430050
OpenAlexW2757173006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.