Evidence map›Paper›PMID 28941306›Full record

ArticleJournal of veterinary internal medicine2017

Influence of Various Factors on Circulating 25(OH) Vitamin D Concentrations in Dogs with Cancer and Healthy Dogs.

N Weidner, J P Woods, P Conlon, K A Meckling, J L Atkinson, J Bayle, A J Makowski, R L Horst, A Verbrugghe

Open access · goldAbstract readComparative Study
In one paragraph

Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
  2. Article
  3. Efficacy of vitamin DThe British journal of nutrition · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Vitamin D status in cats with cardiomyopathy.Journal of veterinary internal medicine · 2020
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Vitamin D status in female dogs with mammary gland tumors.Journal of veterinary internal medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

N WeidnerDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.ORCID http://orcid.org/0000-0002-5106-5045
J P WoodsDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
P ConlonDepartment of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
K A MecklingDepartment of Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, ON, Canada.
J L AtkinsonDepartment of Animal and Poultry Science, Ontario Agricultural College, University of Guelph, Guelph, ON, Canada.
J BayleRoyal Canin Research Center, Aimargues, France.
A J MakowskiHeartland Assays LLC, Ames, IA.
R L HorstHeartland Assays LLC, Ames, IA.
A VerbruggheDepartment of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
University of Guelph · CAHeartland Alliance · USRoyal Darwin Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow blood 25-hydroxyvitamin D (25(OH)D) concentrations have been associated with cancer in dogs. Little research has examined what other factors may affect 25(OH)D concentrations.

objectives(1) To determine whether the presence of cancer (lymphoma, osteosarcoma, or mast cell tumor [MCT]) in dogs is associated with plasma 25(OH)D concentrations and (2) identify other factors related to plasma 25(OH)D concentrations in dogs. ANIMALS: Dogs newly diagnosed with osteosarcoma (n = 21), lymphoma (n = 27), and MCT (n = 21) presented to a tertiary referral oncology center, and healthy, client-owned dogs (n = 23).

methodsAn observational study design was used. Dietary vitamin D intake, sex, age, body condition score (BCS), muscle condition score (MCS), and plasma concentrations of 25(OH)D, 24,25-dihydroxyvitamin D (24,25(OH)

resultsCancer type (P = 0.004), plasma 24,25(OH) CONCLUSIONS AND CLINICAL IMPORTANCE: Results support a relationship between cancer and altered vitamin D metabolism in dogs, mediated by plasma ICa concentrations. The CYP24A1 activity and plasma ICa should be measured in studies examining plasma 25(OH)D concentrations in dogs.

Indexed as

AnimalsCalciumDog DiseasesDogsFemaleLymphomaMaleMast-Cell SarcomaNeoplasmsOsteosarcomaParathyroid HormoneVitamin DVitamin D3 24-Hydroxylase25-hydroxyvitamin DCalciumParathyroid HormoneVitamin DVitamin D3 24-Hydroxylase24,25-dihydroxyvitamin D25-hydroxyvitamin DLymphomaOsteosarcoma

Identifiers

PMID28941306
PMCPMC5697176
OpenAlexW2756680935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.