Evidence map›Paper›PMID 28941256›Full record

ArticleBritish journal of pharmacology2017

Different protein kinase C isoenzymes mediate inhibition of cardiac rapidly activating delayed rectifier K

Xueli Liu, Yuhong Wang, Hua Zhang, Li Shen, Yanfang Xu

Open access · bronzeAbstract read
In one paragraph

Article in British journal of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Obesity Arrhythmias: Role of IL-6 Trans-Signaling.International journal of molecular sciences · 2024
    Review
  3. Angiotensin receptors and αPflugers Archiv : European journal of physiology · 2024
    Article
  4. PKC regulation of ion channels: The involvement of PIPThe Journal of biological chemistry · 2022
    Review
  5. Article
  6. Article
  7. Article
  8. Diacylglycerol kinases regulate TRPV1 channel activity.The Journal of biological chemistry · 2020
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xueli LiuDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China; The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China.
Yuhong WangInstitute of Masteria Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Hua ZhangDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China; The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China.
Li ShenDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China; The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China.
Yanfang XuDepartment of Pharmacology, Hebei Medical University, Shijiazhuang, China; The Key Laboratory of New Drug Pharmacology and Toxicology, Shijiazhuang, China; The Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, China.ORCID http://orcid.org/0000-0001-9332-5418
Hebei Medical University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeElevated angiotensin II (Ang II) and sympathetic activity contributes to a high risk of ventricular arrhythmias in heart disease. The rapidly activating delayed rectifier K EXPERIMENTAL APPROACH: The whole-cell patch-clamp technique was used to record I KEY

resultsA broad spectrum PKC inhibitor Gö6983 (not inhibiting PKCε), a selective cPKC inhibitor Gö6976 and a PKCα-specific inhibitor peptide, blocked the inhibition of I CONCLUSIONS AND IMPLICATIONS: Our results indicated that inhibition of I

Indexed as

Angiotensin IIAnimalsDelayed Rectifier Potassium ChannelsERG1 Potassium ChannelGuinea PigsHEK293 CellsHumansIndolesIsoenzymesMaleMaleimidesMyocytes, CardiacPatch-Clamp TechniquesProtein Kinase CProtein Kinase C-alphaProtein Kinase C-epsilon2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimideAngiotensin IIDelayed Rectifier Potassium ChannelsERG1 Potassium ChannelIndolesIsoenzymesKCNH2 protein, humanMaleimidesProtein Kinase CProtein Kinase C-alphaProtein Kinase C-epsilonProtein Kinase InhibitorsReceptor, Angiotensin, Type 1Receptors, G-Protein-Coupled

Identifiers

PMID28941256
PMCPMC5715974
OpenAlexW2759364043

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.