Evidence map›Paper›PMID 28941061›Full record

ArticleAngewandte Chemie (International ed. in English)2017

Lanthanide-Coordinated Semiconducting Polymer Dots Used for Flow Cytometry and Mass Cytometry.

Xu Wu, Quinn DeGottardi, I-Che Wu, Jiangbo Yu, Li Wu, Fangmao Ye, Chun-Ting Kuo, William W Kwok, Daniel T Chiu

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 46 citations in OpenAlex.

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  13. Ratiometric Barcoding for Mass Cytometry.Analytical chemistry · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xu WuDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.ORCID 0000-0003-1336-9571
Quinn DeGottardiBenaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.
I-Che WuDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.
Jiangbo Yu
Li WuDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.
Fangmao YeDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.
Chun-Ting KuoDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.
William W KwokBenaroya Research Institute at Virginia Mason, Seattle, WA, 98101, USA.
Daniel T ChiuDepartment of Chemistry, University of Washington, Seattle, WA, 98195, USA.
University of Washington · USVirginia Mason Medical Center · US

Funding

Mechanisms for HLA-DQ mediated disease protection and susceptibilityDP3DK097653 · NIDDK · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI KWOK, WILLIAM W. · 2012 to 2012
$3.5M
Ultra-Bright Probes with Ultra-Narrow Emission for Molecular and Cellular AnalysiR21CA186798 · NCI · UNIVERSITY OF WASHINGTON · PI CHIU, DANIEL T · 2014 to 2016
$672k
NCI NIH HHS R21 CA186798NIDDK NIH HHS DP3 DK097653
6 · The paper itself

Abstract

Simultaneous monitoring of biomarkers as well as single-cell analyses based on flow cytometry and mass cytometry are important for investigations of disease mechanisms, drug discovery, and signaling-network studies. Flow cytometry and mass cytometry are complementary to each other; however, probes that can satisfy all the requirements for these two advanced technologies are limited. In this study, we report a probe of lanthanide-coordinated semiconducting polymer dots (Pdots), which possess fluorescence and mass signals. We demonstrated the usage of this dual-functionality probe for both flow cytometry and mass cytometry in a mimetic cell mixture and human peripheral blood mononuclear cells as model systems. The probes not only offer high fluorescence signal for use in flow cytometry, but also show better performance in mass cytometry than the commercially available counterparts.

Indexed as

SemiconductorsBiomarkersFlow CytometryHumansJurkat CellsLanthanoid Series ElementsLeukocytes, MononuclearMCF-7 CellsMicroscopy, Electron, TransmissionMolecular ProbesPolymersSpectrometry, FluorescenceBiomarkersLanthanoid Series ElementsMolecular ProbesPolymersflow cytometryfluorescent probeslanthanidesmass cytometrypolymer nanoparticles

Identifiers

PMID28941061
PMCPMC5687989
OpenAlexW2758463337

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.