SynthesisMolecular nutrition & food research2018
Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent.
Abstract readMeta-Analysis
In one paragraph
Synthesis in Molecular nutrition & food research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- A gene-diet interaction-based score predicts response to dietary fat in the Women's Health Initiative.The American journal of clinical nutrition · 2020Trial
- An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications.Reviews in endocrine & metabolic disorders · 2024Review
- Appraisal of Gene-Environment Interactions in GWAS for Evidence-Based Precision Nutrition Implementation.Current nutrition reports · 2022Review
- Dairy Product Intake and Cardiometabolic Diseases in Northern Sweden: A 33-Year Prospective Cohort Study.Nutrients · 2019Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
63 authors.
Caren E SmithNutrition and Genomics Laboratory, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Jack L FollisUniversity of St Thomas, Houston, TX, USA.
Hassan S DashtiCenter for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.
Toshiko TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Mariaelisa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Amanda M FrettsDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Tuomas O KilpeläinenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Mary K WojczynskiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Kris RichardsonNutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Christina-Alexandra SchulzLUDC, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Yongmei LiuDepartment of Epidemiology & Prevention, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Alexis C Frazier-WoodUSDA / ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.
Esther van EekelenDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Carol WangSchool of Women's and Infants' Health, University of Western Australia, Perth, Australia.
Paul S de VriesHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.
Vera MikkiläDivision of Nutrition, Department of Food and Environmental Sciences, University of Helsinki, Helsinki.
Rebecca RohdeDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Bruce M PsatyDepartments of Medicine, Epidemiology and Health Services, University of Washington, Seattle, WA, USA.
Torben HansenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Mary F FeitosaDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Chao-Qiang LaiUSDA ARS, Nutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Denise K HoustonDepartment of Internal Medicine, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, NC, USA.
Luigi FerruciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
Ulrika EricsonLUDC, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Zhe WangHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Wendy H OddyMenzies Institute for Medical Research, University of Tasmania, Australia.
Ester A L de JongeDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Ilkka SeppäläDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere University School of Medicine, Tampere, Finland.
Anne E JusticeDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Rozenn N LemaitreDepartment of Medicine, University of Washington, Seattle, WA, USA.
Thorkild I A SørensenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Michael A ProvinceDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Laurence D ParnellUSDA ARS, Nutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Melissa E GarciaNational Institute of Aging, Bethesda, MD, USA.
Stefania BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
Marju Orho-MelanderLUDC, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Frits R RosendaalDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
Craig E PennellSchool of Women's and Infants' Health, University of Western Australia, Perth, Australia.
Jessica C Kiefte-de JongDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Mika KähönenDepartment of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland.
Kristin L YoungDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Oluf PedersenNovo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
M Carola ZillikensDepartment of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Olli T RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Kari E NorthDepartment of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
Kim OvervadDepartment of Public Health, Section for Epidemiology, Aarhus University, DK-8000, Aarhus C, Denmark.
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, KY, USA.
Albert HofmanDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere University School of Medicine, Tampere, Finland.
Anne TjønnelandDanish Cancer Society Research Center, Copenhagen, 2100, Denmark.
André G UitterlindenDepartment of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Fernando RivadeneiraDepartment of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Oscar H FrancoDepartment of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
J Bruce GermanDepartment of Food Science and Technology, University of California, Davis, CA, USA.
David S SiscovickNew York Academy of Medicine, New York, NY, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, USA.
José M OrdovásNutrition and Genomics Laboratory, Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MRe-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Brian N Finck · 1999 to 2026
$30.2MGenetic and Environmental Determinants of TriglyceridesU01HL072524 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNETT, DONNA K · 2002 to 2008
$11.9MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MCHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6MGenomewide Association Study of Lipid Response to Fenofibrate and Dietary FatR01HL091357 · NHLBI · UNIVERSITY OF KENTUCKY · PI ARNETT, DONNA K · 2008 to 2018
$5.8MNorth Carolina Translational & Clinical Sciences Institute (NC TraCS)KL2TR001109 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$5.7MGenetic Architecture of Adiposity in Multiple Large CohortsR01DK089256 · NIDDK · WASHINGTON UNIVERSITY · PI BARANSKI, THOMAS JOHN, LIU, CHING-TI · 2010 to 2016
$4.6MThe Aging Genome Association Study "AGE-GAIN"ZIAAG000965 · NIA · NATIONAL INSTITUTE ON AGING · PI FERRUCCI, LUIGI · 2009 to 2025
$4.0MProbing The Dark Matter of the Genome in the NHLBI Family Heart StudyR01HL117078 · NHLBI · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2013 to 2016
$3.0MNCATS NIH HHS KL2 TR001109NCATS NIH HHS UL1 TR001881NCATS NIH HHS UL1 TR002489NHLBI NIH HHS K08 HL112845NHLBI NIH HHS R00 HL130580NHLBI NIH HHS R01 HL091357NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS U01 HL072524NHLBI NIH HHS U01 HL130114NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK089256
Abstract
scopeBody weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption. METHODS AND
resultsA genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10
conclusionBody weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.
Indexed as
Body Mass IndexDairy ProductsPolymorphism, Single NucleotideActinsAdultAgedCohort StudiesCross-Sectional StudiesFemaleGene FrequencyGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedMyosin-Light-Chain PhosphataseACTA2 protein, humanActinsMyosin-Light-Chain PhosphatasePPP1R12A protein, humanbody mass indexCHARGE consortiumdairy intakegenome-wide interaction studymeta-analysis
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