ArticlePigment cell & melanoma research2018
The patterns of birthmarks suggest a novel population of melanocyte precursors arising around the time of gastrulation.
Article in Pigment cell & melanoma research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Re-evaluation of the Anatomical Distribution Patterns in Large Congenital Melanocytic Nevus.Dermatology practical & conceptual · 2025Article
- Segmental corymbiform congenital melanocytic naevi: Implications for melanocytic embryology.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Article
- Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction.Signal transduction and targeted therapy · 2025Article
- Insights into lysosome-related organelle biogenesis: melanosome as a model organelle.Frontiers in cell and developmental biology · 2025Article
- Melanocyte lineage dynamics in development, growth and disease.Development (Cambridge, England) · 2024Review
- Connecting the dots: Melanoma cell of origin, tumor cell plasticity, trans-differentiation, and drug resistance.Pigment cell & melanoma research · 2023Review
- The journey from melanocytes to melanoma.Nature reviews. Cancer · 2023Review
- Alpha-Synuclein and Its Role in Melanocytes.Cells · 2022Article
- Stabilization of β-catenin promotes melanocyte specification at the expense of the Schwann cell lineage.Development (Cambridge, England) · 2022Article
- Tfap2b specifies an embryonic melanocyte stem cell that retains adult multifate potential.Cell reports · 2022Article
- Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report.The Australasian journal of dermatology · 2021Article
- Melanoma Risk and Melanocyte Biology.Acta dermato-venereologica · 2020Review
- Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.The British journal of dermatology · 2020Article
- Phenotypic expansion of POFUT1 loss of function mutations in a disorder featuring segmental dyspigmentation with eczematous and folliculo-centric lesions.American journal of medical genetics. Part A · 2019Article
- Genetic and clinical characterization of 73 Pigmentary Mosaicism patients: revealing the genetic basis of clinical manifestations.Orphanet journal of rare diseases · 2019Article
- A Case of Segmental Vitiligo Along Blaschko's Lines.Annals of dermatology · 2018Article
- The patterns of birthmarks suggest a novel population of melanocyte precursors arising around the time of gastrulation.Pigment cell & melanoma research · 2018Article
Corrections and comments
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2 authors.
Funding
Abstract
Systematic work in the mouse and chicken has mapped out two neural crest-derived pathways of melanocyte precursor migration. With these in mind, this study reappraises the patterns of congenital pigmentary disorders in humans and identifies three recurrent patterns consistent across genetically different diseases. Only two of these are seen in diseases known to be melanocyte cell-autonomous. The segmental pattern correlates well with the classical dorsolateral population from animal studies, demonstrating respect of the midline, cranio-caudal axial mixing, unilateral migration and involvement of key epidermally derived structures. Importantly however, the melanocyte precursors responsible for the non-segmental pattern, which demonstrates circular, bilateral migration centred on the midline, and not involving key epidermally derived structures, have not been identified previously. We propose that this population originates around the time of gastrulation, most likely within the mesoderm, and ultimately resides within the dermis. Whether it contributes to mature melanocytes in non-disease states is not known; however, parallels with the patterns of acquired vitiligo would suggest that it does. The third pattern, hypo- or hyperpigmented fine and whorled Blaschko's lines, is proposed to be non-cell-autonomous.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.