Observational studyArthritis & rheumatology (Hoboken, N.J.)2018
Knee Alignment Is Quantitatively Related to Periarticular Bone Morphometry and Density, Especially in Patients With Osteoarthritis.
Observational study in Arthritis & rheumatology (Hoboken, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- Regional Differences in Knee Osteoporosis Based on Coronal Alignment Phenotype in Patients Undergoing Preoperative CT Imaging.Diagnostics (Basel, Switzerland) · 2026Article
- Subchondral bone density and trabecular morphometry mediate the association between knee malalignment and osteophyte progression in osteoarthritis: data from the osteoarthritis initiative.Clinical rheumatology · 2026Article
- Stage-Dependent Changes in Subchondral Trabecular Bone Mechano-Structure in Primary Knee Osteoarthritis with Varus Malalignment.Journal of functional morphology and kinesiology · 2026Article
- Coronal knee alignment is directly related to knee medial-to-lateral bone density ratio.Journal of experimental orthopaedics · 2026Article
- Assessing intra-rater reliability of peripheral quantitative computed tomography in knee joint bone evaluation on individuals with and without obesity: A GRRAS study.Osteoarthritis imaging · 2026Article
- Article
- Osteoporosis is associated with varus deformity in postmenopausal women with knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2021Article
- Association between knee alignment, osteoarthritis disease severity, and subchondral trabecular bone microarchitecture in patients with knee osteoarthritis: a cross-sectional study.Arthritis research & therapy · 2020Article
- Predictive factors for longer operative times in patients with medial knee osteoarthritis undergoing total knee arthroplasty.Journal of orthopaedicsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveStatic alignment influences knee loading and predicts osteoarthritis (OA) progression. Periarticular bone is important in dispersing forces across the knee, and there is substantial evidence for molecular crosstalk between cartilage and subchondral bone. The aim of this study was to evaluate the relationship between periarticular trabecular bone morphology and bone mineral density (BMD) and knee alignment in OA.
methodsThis was a cross-sectional analysis of participants in the Osteoarthritis Initiative Bone Ancillary Study. Dual x-ray absorptiometry (DXA) was performed to measure tibial periarticular bone mineral density (paBMD). Magnetic resonance imaging of knee trabecular bone was performed to calculate the apparent bone volume fraction (aBVF), apparent trabecular number (aTbN), apparent trabecular spacing (aTbSp), and apparent trabecular thickness (aTbTh). Static alignment was assessed by measuring the hip-knee-ankle (HKA) angle on long-limb films.
resultsThe study group comprised 436 participants (mean ± SD age 65.4 ± 9.2 years, 46% female, mean ± SD body mass index 29.6 ± 4.6 kg/m
conclusionStatic alignment was associated with medial:lateral paBMD in all knees and with medial paBMD and trabecular morphometry in OA knees only. Aberrant knee loading may lead to increased relative subchondral bone density, which is partly related to a higher aBVF and a greater number of thicker trabeculae with smaller intertrabecular spacing. Knee DXA may be a useful early biomarker of knee OA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.