ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2018
Reduced CD200 expression is associated with altered Th1/Th2 cytokine production in placental trophoblasts from preeclampsia.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Preeclamptic Women Have Decreased Circulating IL-10 (Interleukin-10) Values at the Time of Preeclampsia Diagnosis: Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2020Pooled it
- A comprehensive review of the roles of T-cell immunity in preeclampsia.Frontiers in immunology · 2025Review
- Rare Autoinflammatory Neutrophilic Dermatoses in Pregnancy: Literature Review.American journal of clinical dermatology · 2024Review
- Unveiling immune tolerance pathways in preeclampsia placenta: implications for molecular targets and discovery of potential biomarkers.Frontiers in endocrinology · 2024Article
- Biochemical Activation and Regulatory Functions of Trans-Regulatory KLF14 and Its Association with Genetic Polymorphisms.Metabolites · 2023Review
- Significance of placental CD200 expression in patients with preeclampsia: Comparison between early‑ and late‑onset patients.Molecular medicine reports · 2023Article
- Pre-Existing Diabetes Mellitus, Hypertension and KidneyDisease as Risk Factors of Pre-Eclampsia: A Disease of Theories and Its Association with Genetic Polymorphism.International journal of environmental research and public health · 2022Review
- Immunometabolic adaptation and immune plasticity in pregnancy and the bi-directional effects of obesity.Clinical and experimental immunology · 2022Article
- Vitamin D stimulates placental L-type amino acid transporter 1 (LAT1) in preeclampsia.Scientific reports · 2022Article
- Progesterone: A Unique Hormone with Immunomodulatory Roles in Pregnancy.International journal of molecular sciences · 2022Review
- Immune cell infiltration landscape and immune marker molecular typing in preeclampsia.Bioengineered · 2021Article
- Vitamin D stimulates miR-26b-5p to inhibit placental COX-2 expression in preeclampsia.Scientific reports · 2021Article
- The Immunology of Syncytialized Trophoblast.International journal of molecular sciences · 2021Review
- The Role of Inflammation in the Pathogenesis of Preeclampsia.Mediators of inflammation · 2020Review
- Spontaneous superimposed preeclampsia: chronology and expression unveiled by temporal transcriptomic analysis.Physiological genomics · 2019Article
- Role of the Monocyte-Macrophage System in Normal Pregnancy and Preeclampsia.International journal of molecular sciences · 2019Review
- Assessment of levels of D-dimer and interferon-γ in pediatric patients withExperimental and therapeutic medicine · 2018Article
- The Role of Interleukin-10 in the Pathophysiology of Preeclampsia.Current hypertension reports · 2018Review
- Anti-CD200 attenuates concanavalin A induced hepatitis via modulating the imbalance of CD4American journal of translational research · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
problemTo determine if altered trophoblast CD200 and CD200R expressions promote inflammatory cytokine production in preeclamptic placentas. METHODS OF STUDY: Placental tissue CD200 and CD200R expressions were determined by immunostaining. Tissue sections from first-, second-, and third-trimester, normal term, and preeclamptic placentas were used. CD200 and CD200R expressions and cytokine production of TNFα, sTNFR1, INFγ, IL-4, IL-6, IL-8, and IL-10 were determined in trophoblasts from normal and preeclamptic placentas and in normal trophoblasts transfected with CD200 siRNA.
resultsCD200, but not CD200R, expression was significantly reduced in trophoblasts from preeclamptic compared to normal placentas. Trophoblast from preeclamptic placentas and trophoblast transfected with CD200 siRNA produced significantly more TNFα, sTNFR1, IL-6, and IL-8, but significantly less IL-10, than trophoblasts from normal control placentas.
conclusionDownregulation of CD200 expression resulted in an imbalance of increased Th1 cytokine and decreased Th2 cytokine production in placental trophoblasts in preeclampsia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.